The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes

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	The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes
	Zhang, XM; Dai, LR; Wang, AH; Wolk, C; Dobner, B; Brezesinski, G; Tang, YQ; Wang, XY; Li, JB
刊名	SCIENTIFIC REPORTS
	2015
卷号	5 期号:0 页码:16559
通讯作者	Li, JB (reprint author), Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China.
英文摘要	Highly dynamic tubular structures in cells are responsible for exchanges between organelles. Compared with bacterial invasion, the most affordable and least toxic lipids were found in this study to be gentle and safe exogenous stimuli for the triggering of membrane tubules. A specific lipid system was internalized by NIH3T3 cells. Following cellular uptake, the constructed liposomes traveled towards the nucleus in aggregations and were gradually distributed into moving vesicles and tubules in the cytosol. The triggered tubules proceeded, retreated or fluctuated along the cytoskeleton and were highly dynamic, moving quickly (up to several microns per second), and breaking and fusing frequently. These elongated tubules could also fuse with one another, giving rise to polygonal membrane networks. These lipid systems, with the novel property of accelerating intracellular transport, provide a new paradigm for investigating cellular dynamics.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	ENDOPLASMIC-RETICULUM ; GENE DELIVERY ; LIVING CELLS ; CATIONIC LIPOSOMES ; TRANSPORT ; LIPIDS ; MICROTUBULES ; TRAFFICKING ; BEHAVIOR ; PROTEIN
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/20797]
专题	理论物理研究所_理论物理所1978-2010年知识产出
推荐引用方式 GB/T 7714	Zhang, XM,Dai, LR,Wang, AH,et al. The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes[J]. SCIENTIFIC REPORTS,2015,5(0):16559.
APA	Zhang, XM.,Dai, LR.,Wang, AH.,Wolk, C.,Dobner, B.,...&Li, JB.(2015).The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes.SCIENTIFIC REPORTS,5(0),16559.
MLA	Zhang, XM,et al."The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes".SCIENTIFIC REPORTS 5.0(2015):16559.