Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR

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	Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR
	Wu, L; Yin, XZ; Guo, Z; Tong, YJ; Feng, J; York, P; Xiao, TQ; Chen, M; Gu, JK; Zhang, JW
刊名	EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2016
卷号	84 期号:-页码:132—138
关键词	DRUG-DELIVERY SYSTEMS TASTE MASKING FILM COATINGS SPECTROMICROSCOPY OPTIMIZATION FORMULATION PROTECTION RELEASE CAPSULE DESIGN
ISSN号	0928-0987
通讯作者	Gu, JK ; Zhang, JW (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China. ; Chen, M (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China.
英文摘要	Osmotic pump tablets are reliable oral controlled drug delivery systems based on their semipermeable membrane coating. This research used synchrotron radiation-based Fourier transform infrared (SR-FTIR) microspectroscopy and imaging to investigate the hydration induced material transfer in the membranes of osmotic pump tablets. SR-FTIR was applied to record and map the chemical information of a micro-region of the membranes, composed of cellulose acetate (CA, as the water insoluble matrix) and polyethylene glycol (PEG, as the soluble pore forming agent and plasticizing agent). The microstructure and chemical change of membranes hydrated for 0, 5, 10 and 30 min were measured using SR-FTIR, combined with scanning electronic microscopy and atom force microscopy. The SR-FTIR microspectroscopy results indicated that there was a major change at the absorption range of 2700-3100 cm(-1) in the membranes after different periods of hydration time. The absorption bands at 2870-2880 cm(-1) and 2950-2960 cm(-1) were assigned to represent CA and PEG, respectively. The chemical group signal distribution illustrated by the ratio of PEG to CA demonstrated that the trigger of drug release in the preliminary stage was due to the rapid transfer of PEG into liquid medium with a sharp decrease of PEG in the membranes. The SR-FTIR mapping results have demonstrated the hydration induced material transfer in the membranes of osmotic pump tablets and enabled reassessment of the drug release mechanism of membrane controlled osmotic pump systems. (C) 2016 Elsevier B.V. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000370680200015
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/25748]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Wu, L,Yin, XZ,Guo, Z,et al. Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2016,84(-):132—138.
APA	Wu, L.,Yin, XZ.,Guo, Z.,Tong, YJ.,Feng, J.,...&Zhang, JW.(2016).Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,84(-),132—138.
MLA	Wu, L,et al."Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 84.-(2016):132—138.