Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2

CORC > 天津工业生物技术研究所 > 生物催化与绿色化工朱敦明 > 期刊论文

	Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2
	Yang, Beibei 1,2,3; Wang, Yu 1,2; Chen, Xi 1,2; Feng, Jinhui 1,2; Wu, Qiaqing 1,2; Zhu, Dunming 1,2; Ma, Yanhe 1,2
刊名	TETRAHEDRON
	2014-01-07
卷号	70 期号:1 页码:41-46
关键词	Steroids Biotransformation Testolactone Testolic acid Penicillium simplicissimum Metabolic pathways
英文摘要	The biotransformations of a range of steroidal compounds, including 17 alpha-hydroxy progesterone, progesterone, testosterone, androst-4-ene-3,17-dione (AD), pregnenolone, and dehydroepiandrosterone (DHEA), by Penicillium simplicissimum WY134-2 have been investigated. In all the cases, testolic acid and testololactone were detected, and the acid was converted to the lactone when pH was adjusted to 1, leading to isolation of testololactone in 25%-96% yields. Especially for progesterone and testosterone, the isolated yields were 93% and 96% with substrate concentration being 3 g/L, suggesting that P. simplicissimum WY134-2 may be used for the synthesis of testololactone. The results revealed the multi-functional catalytic activity of P. simplicissimum WY134-2 toward steroids for the first time. The possible reaction pathways of steroids promoted by this strain were discussed. (C) 2013 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	AROMATASE INHIBITORS ; LACTONIZATION ; 2-METHOXYESTRADIOL ; TRANSFORMATION ; MONOOXYGENASE ; PROGESTERONE ; PURIFICATION ; FUNGUS ; BREAST
收录类别	SCI
语种	英语
WOS记录号	WOS:000330097500005
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1380]
专题	天津工业生物技术研究所_生物催化与绿色化工朱敦明_期刊论文
作者单位	1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China 2.Chinese Acad Sci, Tianjin Engn Ctr Biocatalyt Technol, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang, Beibei,Wang, Yu,Chen, Xi,et al. Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2[J]. TETRAHEDRON,2014,70(1):41-46.
APA	Yang, Beibei.,Wang, Yu.,Chen, Xi.,Feng, Jinhui.,Wu, Qiaqing.,...&Ma, Yanhe.(2014).Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2.TETRAHEDRON,70(1),41-46.
MLA	Yang, Beibei,et al."Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2".TETRAHEDRON 70.1(2014):41-46.