Induced Production of New Diterpenoids in the Fungus Penicillium funiculosum

	Induced Production of New Diterpenoids in the Fungus Penicillium funiculosum
	Liu, Dong-Ze 1; Liang, Bo-Wen 2; Li, Xiao-Fei 2; Liu, Qiang 2
刊名	NATURAL PRODUCT COMMUNICATIONS
	2014-05-01
卷号	9 期号:5 页码:607-608
关键词	Diterpenoids Penicillium funiculosum Epigenetic modifier Biosynthesis
英文摘要	The supplementation of a DNA methyltransferase inhibitor, 5-azacytidine (5-AZ), to the culture medium of Penicillium funiculosum, dramatically altered its metabolic profiles. Analysis of the culture broth extract led to the isolation of two new prenyleudesmane diterpenoids (1-2). The isolated compounds were further evaluated for their cytotoxic and antibacterial activities. Our findings confirmed that the use of chemical epigenetic modifiers is an effective technique for promoting the expression of silent biosynthetic pathways to produce unique secondary metabolites.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Medicinal ; Food Science & Technology
研究领域[WOS]	Pharmacology & Pharmacy ; Food Science & Technology
收录类别	SCI
语种	英语
WOS记录号	WOS:000336512700002
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1403]
专题	天津工业生物技术研究所_发酵过程姜文侠_期刊论文
作者单位	1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China 2.Northeast Agr Univ, Harbin 150030, Peoples R China
推荐引用方式 GB/T 7714	Liu, Dong-Ze,Liang, Bo-Wen,Li, Xiao-Fei,et al. Induced Production of New Diterpenoids in the Fungus Penicillium funiculosum[J]. NATURAL PRODUCT COMMUNICATIONS,2014,9(5):607-608.
APA	Liu, Dong-Ze,Liang, Bo-Wen,Li, Xiao-Fei,&Liu, Qiang.(2014).Induced Production of New Diterpenoids in the Fungus Penicillium funiculosum.NATURAL PRODUCT COMMUNICATIONS,9(5),607-608.
MLA	Liu, Dong-Ze,et al."Induced Production of New Diterpenoids in the Fungus Penicillium funiculosum".NATURAL PRODUCT COMMUNICATIONS 9.5(2014):607-608.