An amorphous calcium phosphate nanocomposite for storing and sustained release of IgY protein with antibacterial activity

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	An amorphous calcium phosphate nanocomposite for storing and sustained release of IgY protein with antibacterial activity
	Chen, Feng 1; Yang, Bin 2; Qi, Chao 1; Sun, Tuan-Wei 1; Jiang, Ying-Ying 1; Wu, Jin 1; Chen, Xi 2; Zhu, Ying-Jie 1
刊名	RSC ADVANCES
	2015
卷号	5 期号:122 页码:100682-100688
英文摘要	The synthesis of multifunctional biomaterials with antibacterial activity and remineralization effect on demineralized enamel remains a great challenge in the dental research field. Herein, we use chicken immunoglobulin Y (IgY) and amorphous calcium phosphate (ACP) nanospheres to prepare a nanocomposite with the multifunctional properties of antibacterial activity and remineralized effect. ACP nanospheres and La-ACP nanospheres with an amorphous structure are prepared by a simple coprecipitation method. Then, the as-prepared ACP nanospheres and La-ACP nanospheres which have high protein adsorption capacity are functionalized by adsorbing IgY molecules. After loading IgY, the ACP nanospheres and La-ACP nanospheres exhibit significant antibacterial activity against Sreptococcus mutans (S. mutans). Through the sustained release of IgY molecules and the mineralization of ACP nanospheres in simulated saliva fluid (SSF), the IgY-loaded ACP nanospheres have potential application in simultaneous inhibition of harmful oral bacteria and remineralization of demineralized tooth enamel. Due to the high biocompatibility, the as-prepared IgY-loaded ACP nanospheres and IgY-loaded La-ACP nanospheres are promising for prophylaxis and treatment of dental caries.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	SENSITIVE DRUG-RELEASE ; YOLK ANTIBODIES IGY ; STREPTOCOCCUS-MUTANS ; DENTAL-CARIES ; EGG-YOLK ; PASSIVE-IMMUNIZATION ; ADSORPTION ; NANOPARTICLES ; NANOSPHERES ; DELIVERY
收录类别	SCI
语种	英语
WOS记录号	WOS:000365581700032
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/8637]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Super Micr, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Prevent Dent, Shanghai 200011, Peoples R China
推荐引用方式 GB/T 7714	Chen, Feng,Yang, Bin,Qi, Chao,et al. An amorphous calcium phosphate nanocomposite for storing and sustained release of IgY protein with antibacterial activity[J]. RSC ADVANCES,2015,5(122):100682-100688.
APA	Chen, Feng.,Yang, Bin.,Qi, Chao.,Sun, Tuan-Wei.,Jiang, Ying-Ying.,...&Zhu, Ying-Jie.(2015).An amorphous calcium phosphate nanocomposite for storing and sustained release of IgY protein with antibacterial activity.RSC ADVANCES,5(122),100682-100688.
MLA	Chen, Feng,et al."An amorphous calcium phosphate nanocomposite for storing and sustained release of IgY protein with antibacterial activity".RSC ADVANCES 5.122(2015):100682-100688.