X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization
	Fan, Wenpei 1; Bu, Wenbo 1; Zhang, Zhen 2; Shen, Bo 3; Zhang, Hui 2; He, Qianjun 1; Ni, Dalong 1; Cui, Zhaowen 1; Zhao, Kuaile 2; Bu, Jiwen 4
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2015-11-16
卷号	54 期号:47 页码:14026-14030
关键词	hypoxic radiosensitization luminescent imaging NO release on-demand therapy X-ray radiation
英文摘要	Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	UP-CONVERSION NANOPARTICLES ; ANTICANCER DRUG-DELIVERY ; NITRIC-OXIDE ; BIOMEDICAL APPLICATIONS ; SILICA NANOPARTICLES ; MESOPOROUS SILICA ; CANCER-THERAPY ; NANOTHERANOSTICS ; NANOPHOSPHORS ; RADIOTHERAPY
收录类别	SCI
语种	英语
WOS记录号	WOS:000367722500031
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/8193]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China 3.Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Fan, Wenpei,Bu, Wenbo,Zhang, Zhen,et al. X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(47):14026-14030.
APA	Fan, Wenpei.,Bu, Wenbo.,Zhang, Zhen.,Shen, Bo.,Zhang, Hui.,...&Shi, Jianlin.(2015).X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(47),14026-14030.
MLA	Fan, Wenpei,et al."X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.47(2015):14026-14030.