Microbiota-based Signature of Gingivitis Treatments: A Randomized Study

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	Microbiota-based Signature of Gingivitis Treatments: A Randomized Study
	Huang, Shi 1,2,7,8; Li, Zhen 3; He, Tao 4; Bo, Cunpei 1,2; Chang, Jinlan 5; Li, Lin 5; He, Yanyan 5; Liu, Jiquan 6; Charbonneau, Duane 4; Li, Rui 6
刊名	SCIENTIFIC REPORTS
	2016-04-20
卷号	6
英文摘要	Plaque-induced gingivitis can be alleviated by various treatment regimens. To probe the impacts of various anti-gingivitis treatments on plaque microflora, here a double blinded, randomized controlled trial of 91 adults with moderate gingivitis was designed with two anti-gingivitis regimens: the brush-alone treatment and the brush-plus-rinse treatment. In the later group, more reduction in both Plaque Index (TMQHI) and Gingival Index (mean MGI) at Day 3, Day 11 and Day 27 was evident, and more dramatic changes were found between baseline and other time points for both supragingival plaque microbiota structure and salivary metabonomic profiles. A comparison of plaque microbiota changes was also performed between these two treatments and a third dataset where 50 subjects received regimen of dental scaling. Only Actinobaculum, TM7 and Leptotrichia were consistently reduced by all the three treatments, whereas the different microbial signatures of the three treatments during gingivitis relieve indicate distinct mechanisms of action. Our study suggests that microbiota based signatures can serve as a valuable approach for understanding and potentially comparing the modes of action for clinical treatments and oral-care products in the future.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	CETYLPYRIDINIUM CHLORIDE MOUTHRINSES ; CHAIN FATTY-ACIDS ; PERIODONTAL-DISEASE ; ANTIMICROBIAL EFFICACY ; ORAL MICROBIOTA ; DENTAL-CARIES ; REVEALS ; CHLORHEXIDINE ; BACTERIA ; PLAQUE
收录类别	SCI
语种	英语
WOS记录号	WOS:000374378000001
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/8265]
专题	青岛生物能源与过程研究所_单细胞中心
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Single Cell Ctr, Qingdao 266101, Shandong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao 266101, Shandong, Peoples R China 3.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing 100730, Peoples R China 4.Procter & Gamble Mason Business Int, Cincinnati, OH 45040 USA 5.Procter & Gamble Innovat Ctr, Beijing 101312, Peoples R China 6.Procter & Gamble Int Operat SA SG Branch, Singapore 138547, Singapore 7.Sinodanish Ctr Educ & Res, Beijing 100190, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Huang, Shi,Li, Zhen,He, Tao,et al. Microbiota-based Signature of Gingivitis Treatments: A Randomized Study[J]. SCIENTIFIC REPORTS,2016,6.
APA	Huang, Shi.,Li, Zhen.,He, Tao.,Bo, Cunpei.,Chang, Jinlan.,...&Xu, Jian.(2016).Microbiota-based Signature of Gingivitis Treatments: A Randomized Study.SCIENTIFIC REPORTS,6.
MLA	Huang, Shi,et al."Microbiota-based Signature of Gingivitis Treatments: A Randomized Study".SCIENTIFIC REPORTS 6(2016).