Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium

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	Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium
	Guo, Zhixing; Li, Xiaoli; Li, Jianfang; Yang, Xuefei; Zhou, Yuan; Lu, Chunhua; Shen, Yuemao
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2016-09-02
卷号	477 期号:4 页码:998-1004
关键词	Type three secretion system (T3SS) Licoflavonol Salmonella enterica serovar Typhimurium
英文摘要	As an important food-borne human pathogen, Salmonella enterica serovar Typhimurium depends on its type III secretion system (T3SS) as a major virulence factor to cause disease all over the world. The T3SS secretes effector proteins to facilitate invasion into host cells. In this study, twenty prenylated flavonoids (1-20) were screened for their anti-T3SS activity, revealing that several analogs exhibited strong inhibitory effects on the secretion of Salmonella pathogenicity island 1 (SPI-1)-associated effector proteins without affecting the growth of bacteria and the secretion of the flagellar protein FliC. Among the flavonoids 1-20, licoflavonol (20) exhibited a strong inhibitory effect on the secretion of the SPI-1 effector proteins via regulating the transcription of the SicA/InvF genes, and the transportation of the effector protein SipC. In summary, licoflavonol, a novel natural inhibitor of Salmonella T3SS, could be a promising candidate for novel type of anti-virulence drugs. (C) 2016 Elsevier Inc. All rights reserved.
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	III SECRETION ; PRENYLATED FLAVONOIDS ; PROTEIN SECRETION ; TRANSPORTER ; RESISTANCE
收录类别	SCI
语种	英语
WOS记录号	WOS:000380969300075
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/28517]
专题	昆明植物研究所_资源植物与生物技术所级重点实验室
推荐引用方式 GB/T 7714	Guo, Zhixing,Li, Xiaoli,Li, Jianfang,et al. Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,477(4):998-1004.
APA	Guo, Zhixing.,Li, Xiaoli.,Li, Jianfang.,Yang, Xuefei.,Zhou, Yuan.,...&Shen, Yuemao.(2016).Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,477(4),998-1004.
MLA	Guo, Zhixing,et al."Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 477.4(2016):998-1004.