Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense
	Zhu, Yin-Di 1,2; Wu, Hai-Feng 1,2; Ma, Guo-Xu 1,2; Chen, Rong-Chang 1,2; Long, Hai-Lin 3; Zuo, Zhi-Li4 ; Luo, Yun 1,2; Zhu, Nai-Liang 1,2; Hou, Bo 4; Xu, Xu-Dong 1,2
刊名	RSC ADVANCES
	2016
卷号	6 期号:9 页码:7260-7266
英文摘要	Six novel flavonoid-triterpene saponin meroterpenoids, clinoposides A-F (1-6), with two unusual skeletons were isolated from Clinopodium chinense. Clinoposides A-F represent a new class of isopentenyl flavonoid saponin. Their structures were determined based on spectroscopic data and chemical methods. The relative and absolute stereochemistries were assigned using a combination of NOESY and ECD. A possible biogenetic pathway for 1-6 is proposed. The protective effects of clinoposides A-F against H2O2-induced H9c2 cardiomyocyte injury were tested, and all compounds exhibited significantly dose-dependent effects, clinoposides B, D and F showed better protective effects as evidence by increased levels of SOD, CAT and GSH-Px but reduced MDA, LDH, caspase-3 and -9 levels.
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	FLAVONOIDS
收录类别	SCI
语种	英语
WOS记录号	WOS:000369515500046
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25953]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100193, Peoples R China 2.Chinese Acad Med Sci, Beijing 100193, Peoples R China 3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Yin-Di,Wu, Hai-Feng,Ma, Guo-Xu,et al. Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense[J]. RSC ADVANCES,2016,6(9):7260-7266.
APA	Zhu, Yin-Di.,Wu, Hai-Feng.,Ma, Guo-Xu.,Chen, Rong-Chang.,Long, Hai-Lin.,...&Yang, Jun-Shan.(2016).Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense.RSC ADVANCES,6(9),7260-7266.
MLA	Zhu, Yin-Di,et al."Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense".RSC ADVANCES 6.9(2016):7260-7266.