The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas

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	The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas
	Li, Meijia1,3 ; Qiu, Limei 1; Wang, Lingling 1,2; Wang, Weilin1,3 ; Xin, Lusheng1,3 ; Li, Yiqun 1,3; Liu, Zhaoqun1,3 ; Song, Linsheng 2
刊名	FISH & SHELLFISH IMMUNOLOGY
	2016-05-01
卷号	52 页码:16-22
关键词	Crassostrea gigas Inhibitory neurotransmitter gamma-aminobutyric acid Immunomodulation Immune response
英文摘要	gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter to suppress the immune-mediated pro inflammatory reactions, and it has been used in the treatment of many inflammation-related diseases in vertebrates, while its immunomodulatory role in invertebrates has never been reported. In the present study, GABA was found to exist in the hemolymph of Pacific oyster Crassostrea gigas, and its concentration decreased slightly from 8.00 +/- 0.37 mu mol L-1 at normal condition to 7.73 +/- 0.15 mu mol L-1 at 6 h after LPS stimulation, and then increased to 9.34 +/- 0.15 mu mol L-1, 8.86 +/- 0.68 mu mol L-1 at 12 h and 48 h, respectively. After LPS stimulation, the mRNA expressions of pro-inflammatory cytokines (CgIL-17 and CgTNF) and immune effectors (CgSOD and CgBPI), and the protein expression of NOS increased significantly, and these increased trends were remarkably inhibited by GABA stimulation. At the same time, the phagocytosis rate and apoptosis rate of immunocytes also increased obviously after LPS stimulation, whereas the increase was repressed with the addition of GABA. The results collectively demonstrated that GABA was an indispensable inhibitory agent for both humoral and cellular immune response, which mainly functioned at the late phase of immune response to avoid the excess immune reactions and maintain the immune homeostasis. (C) 2016 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000375165200003
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/131034]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Dalian Ocean Univ, Key Lab Mariculture & Stock Enhancement North Chi, Minist Agr, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Meijia,Qiu, Limei,Wang, Lingling,et al. The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2016,52:16-22.
APA	Li, Meijia.,Qiu, Limei.,Wang, Lingling.,Wang, Weilin.,Xin, Lusheng.,...&Song, Linsheng.(2016).The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,52,16-22.
MLA	Li, Meijia,et al."The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 52(2016):16-22.