Organocatalytic aldol and domino Michael-aldol reactions of alpha, alpha-difluoro-beta-keto esters with acetone

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	Organocatalytic aldol and domino Michael-aldol reactions of alpha, alpha-difluoro-beta-keto esters with acetone
	Zhao Y(赵燕); Wang XJ(王小进); Cai CX(蔡晨新); Liu JT(刘金涛)
刊名	J. Fluor. Chem.
	2014
卷号	165 页码:61-66
其他题名	有机催化的α,α-二氟-β-羰基酯与丙酮的aldol和domino Michael-aldol反应
通讯作者	刘金涛
英文摘要	Organocatalyzed reactions of alpha,alpha-difluoro-beta-keto esters with acetone were demonstrated. In the presence of L-proline, the Aldol reaction occurred under mild conditions to give the corresponding tertiary alpha,alpha-difluoroalcohols in good yields with high enantioselectivities. Using pyrrolidine as catalyst, the domino Michael-aldol reaction took place readily to give the corresponding addition products in high yields with excellent diastereoselectivities. (C) 2014 Elsevier B.V. All rights reserved.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.jfluchem.2014.06.010
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/38839]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
作者单位	中科院上海有机化学研究所
推荐引用方式 GB/T 7714	Zhao Y,Wang XJ,Cai CX,et al. Organocatalytic aldol and domino Michael-aldol reactions of alpha, alpha-difluoro-beta-keto esters with acetone[J]. J. Fluor. Chem.,2014,165:61-66.
APA	赵燕,王小进,蔡晨新,&刘金涛.(2014).Organocatalytic aldol and domino Michael-aldol reactions of alpha, alpha-difluoro-beta-keto esters with acetone.J. Fluor. Chem.,165,61-66.
MLA	赵燕,et al."Organocatalytic aldol and domino Michael-aldol reactions of alpha, alpha-difluoro-beta-keto esters with acetone".J. Fluor. Chem. 165(2014):61-66.