Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes

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	Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes
	Zhao Y(赵燕)1; Wang XJ(王小进)1; Lin Y(林云)1; Cai CX(蔡晨新)1; Liu JT(刘金涛)1
刊名	Tetrahedron
	2014
卷号	70 期号:15 页码:2523-2528
其他题名	1,3-二羰基化合物与β-氟烷基-α-硝基烯烃的高对映选择性Michael加成反应
通讯作者	刘金涛
英文摘要	Cinchona alkaloid catalysts were used in the Michael addition reaction of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes for the first time. The catalytic system performed well over a broad scope of substrates including beta-keto esters and 1,3-diketones with high diastereoselectivities and excellent enantioselectivities (up to 99% ee) under mild conditions. A wide range of useful fluorinated chiral building blocks was synthesized. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tet.2014.02.062
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/38836]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
作者单位	1.中科院上海有机化学研究所 2.南京师范大学
推荐引用方式 GB/T 7714	Zhao Y,Wang XJ,Lin Y,et al. Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes[J]. Tetrahedron,2014,70(15):2523-2528.
APA	赵燕,王小进,林云,蔡晨新,&刘金涛.(2014).Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes.Tetrahedron,70(15),2523-2528.
MLA	赵燕,et al."Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes".Tetrahedron 70.15(2014):2523-2528.