SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds

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	SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds
	Liu X(刘旭); Han ZB(韩召斌); Wang Z(王正); Ding KL(丁奎岭)
刊名	Angew. Chem.-Int. Edit.
	2014
卷号	53 期号:7 页码:1978-1982
其他题名	SpinPhox/铱(I)催化环状alpha-亚烷基羰基化合物的不对称氢化
通讯作者	丁奎岭
英文摘要	Optically active medium-sized cyclic carbonyl compounds bearing an -chiral carbon center are of interest in pharmaceutical sciences and asymmetric synthesis. Herein, SpinPhox/Ir-I catalysts have been demonstrated to be highly enantioselective in the asymmetric hydrogenation of the CC bonds in the exocyclic ,-unsaturated cyclic carbonyls, including a broad range of -alkylidene lactams, unsaturated cyclic ketones, and lactones. It is noteworthy that the procedure can be successfully used in the asymmetric hydrogenation of the challenging -alkylidenelactam substrates with six- or seven-membered rings, thus affording the corresponding optically active carbonyl compounds with an -chiral carbon center in generally excellent enantiomeric excesses (up to 98%ee). Synthetic utility of the protocol has also been demonstrated in the asymmetric synthesis of the anti-inflammatory drug loxoprofen and its analogue, as well as biologically important epsilon-aminocaproic acid derivatives.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/anie.201309521
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/38998]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	中科院上海有机化学研究所
推荐引用方式 GB/T 7714	Liu X,Han ZB,Wang Z,et al. SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds[J]. Angew. Chem.-Int. Edit.,2014,53(7):1978-1982.
APA	刘旭,韩召斌,王正,&丁奎岭.(2014).SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds.Angew. Chem.-Int. Edit.,53(7),1978-1982.
MLA	刘旭,et al."SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds".Angew. Chem.-Int. Edit. 53.7(2014):1978-1982.