A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study

	A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study
	Korotcov, A; Shan, LA; Meng, HA; Wang, TX; Sridhar, R; Zhao, YL; Liang, XJ; Wang, PC; Meng H(孟幻); Zhao YL(赵宇亮)
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2010
卷号	10 期号:11 页码:7545-7549
关键词	Targeted Drug Delivery Dynamic Contrast Enhancement (DCE)-MRI Cancer Liposome Transferrin Nanoparticle
通讯作者	[Korotcov, Alexandru ; Shan, Liang ; Wang, Tongxin ; Wang, Paul C.] Howard Univ, Dept Radiol, Washington, DC 20060 USA ; [Meng, Huan ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Liang, Xing-Jie] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Sridhar, Rajagopalan] Howard Univ, Dept Radiat Oncol, Washington, DC 20060 USA
英文摘要	We have developed and tested a liposomal nanocomplex system, which contains Gd-DTPA as a payload and transferrin on the surface, as a tumor specific targeting MRI contrast agent for studying prostate cancer tumors in mice. In vivo, the probe significantly enhanced the MRI signal. The image contrast between the peripheral region of the tumor and the non-involved muscle was nearly 50% higher two hours after administration of the nanocomplex. The liposomal nanocomplex increased the amount of Gd accumulated in tumors by factor 2.8 compared to that accumulated by using Magnevist alone. Moreover, the heterogeneous MRI image features correlate well with the tumor pathology. The image enhancement patterns can be used for cancer prognosis and non-invasive monitoring of the response to therapy.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
原文出处	SCI
语种	英语
WOS记录号	WOS:000283621300128
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/240122]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Korotcov, A,Shan, LA,Meng, HA,et al. A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(11):7545-7549.
APA	Korotcov, A.,Shan, LA.,Meng, HA.,Wang, TX.,Sridhar, R.,...&赵宇亮.(2010).A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(11),7545-7549.
MLA	Korotcov, A,et al."A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.11(2010):7545-7549.