Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine

	Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine
	Shi WQ(石伟群); Shi, WQ; Ni, MN; Kong, FQ; Sui, L; Hu, J; Xu, DD; Li, YM; Xu DD(徐殿斗)
刊名	RADIATION PHYSICS AND CHEMISTRY
	2008
卷号	77 期号:10-12 页码:1290-1293
关键词	3-nitrotyrosine gamma irradiation PBR322 DNA strand breaks
通讯作者	[Shi, Wei-Qun ; Xu, Dian-Dou] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Ni, Mei-Nan ; Kong, Fu-Quan ; Sui, Li] China Inst Atom Energy, Dept Nucl Phys, Beijing, Peoples R China ; [Hu, Jia ; Li, Yan-Mei] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China
英文摘要	3-Nitrotyrosine(3-NY) has been reported as a potential source of reactive oxygen species (ROSs). In this work, plasmid pBR322 DNA was irradiated by gamma rays in aqueous solution in presence and absence of 3-NY, DNA strand breaks were analyzed by neutral electrophoresis followed by quantification with image analysis software. It was found that the presence of 3-NY could effectively reduce radiation-induced DNA strand breaks. A side-by-side comparison was performed between 3-NY and tyrosine, the results showed that the protective role 3-NY was comparable with tyrosine, which might imply that protein tyrosine nitration might not significantly decrease its ability as a free radical scavenger. (C) 2008 Elsevier Ltd. All rights reserved.
学科主题	Chemistry; Nuclear Science & Technology; Physics
类目[WOS]	Chemistry, Physical ; Nuclear Science & Technology ; Physics, Atomic, Molecular & Chemical
研究领域[WOS]	Chemistry ; Nuclear Science & Technology ; Physics
原文出处	SCI
语种	英语
WOS记录号	WOS:000259798400033
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/239258]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Shi WQ,Shi, WQ,Ni, MN,et al. Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine[J]. RADIATION PHYSICS AND CHEMISTRY,2008,77(10-12):1290-1293.
APA	石伟群.,Shi, WQ.,Ni, MN.,Kong, FQ.,Sui, L.,...&徐殿斗.(2008).Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine.RADIATION PHYSICS AND CHEMISTRY,77(10-12),1290-1293.
MLA	石伟群,et al."Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine".RADIATION PHYSICS AND CHEMISTRY 77.10-12(2008):1290-1293.