Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis

	Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis
	Zhang J(张杰); Chen Q(陈启); Liu NQ(刘年庆); Li FL(李福亮); Zhang, J; Liu, Q; Chen, Q; Liu, NQ; Li, FL; Lu, ZB
刊名	FASEB JOURNAL
	2006
卷号	20 期号:8 页码:1212-+
关键词	Alzheimer's disease A beta copper
通讯作者	Acad Sinica, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China ; Salk Inst Biol Studies, La Jolla, CA 92037 USA ; Acad Sinica, Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100101, Peoples R China ; Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100037, Peoples R China ; Acad Sinica, Inst High Energy Phys, Sychrotron Radiat Lab, Beijing 100101, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
英文摘要	Nicotine reduces beta-amyloidosis and has a beneficial effect against Alzheimer's disease (AD), but the underlying mechanism is not clear. The abnormal interactions of beta-amyloid (A beta) with metal ions such as copper and zinc are implicated in the process of A beta deposition in AD brains. In the present study, we investigated the effect of nicotine on metal homeostasis in the hippocampus and cortex of APP(V717I) ( London mutant form of APP) transgenic mice. A significant reduction in the metal contents of copper and zinc in senile plaques and neuropil is observed after nicotine treatment. The densities of copper and zinc distributions in a subfield of the hippocampus CA1 region are also reduced after nicotine treatment. We further studied the mechanism of nicotine-mediated effect on metal homeostasis by using SH-SY5Y cells overexpressing the Swedish mutant form of human APP (APPsw). Nicotine treatment decreases the intracellular copper concentration and attenuates A beta-mediated neurotoxicity facilitated by the addition of copper, and these effects are independent of the activation of nicotinic acetylcholine-receptor. These data suggest that the effect of nicotine on reducing beta-amyloidosis is partly mediated by regulating metal homeostasis.
学科主题	Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Biology ; Cell Biology
研究领域[WOS]	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
原文出处	SCI
语种	英语
WOS记录号	WOS:000240210300029
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/239189]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhang J,Chen Q,Liu NQ,et al. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis[J]. FASEB JOURNAL,2006,20(8):1212-+.
APA	张杰.,陈启.,刘年庆.,李福亮.,Zhang, J.,...&Zhao, BL.(2006).Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.FASEB JOURNAL,20(8),1212-+.
MLA	张杰,et al."Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis".FASEB JOURNAL 20.8(2006):1212-+.