Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans

	Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans
	Liu CP(刘超培); Xu R(许锐); Gao ZQ(高增强); Xu JH(徐建华); Hou HF(侯海峰); Li LQ(李丽琴); She Z(佘准); 刘鹏(多); Dong YH(董宇辉); Liu, CP
刊名	ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
	2010
卷号	66 期号:5 页码:498-502
通讯作者	[Liu, Chao-Pei ; Xu, Rui ; Gao, Zeng-Qiang ; Xu, Jian-Hua ; Hou, Hai-Feng ; Li, Li-Qin ; She, Zhun ; Liu, Peng ; Dong, Yu-Hui] Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China ; [Liu, Chao-Pei ; Li, Li-Qin ; She, Zhun] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; [Li, Lan-Fen ; Su, Xiao-Dong] Peking Univ, Coll Life Sci, Natl Lab Prot Engn & Plant Genet Engn, Beijing 100871, Peoples R China
英文摘要	Orotate phosphoribosyltransferase (OPRTase) catalyzes the OMP-forming step in de novo pyrimidine-nucleotide biosynthesis. Here, the crystal structure of OPRTase from the caries pathogen Streptococcus mutans is reported at 2.4 angstrom resolution. S. mutans OPRTase forms a symmetric dimer and each monomer binds two sulfates at the active sites. The structural symmetry of the sulfate-binding sites and the missing loops in this structure are consistent with a symmetric catalysis mechanism.
学科主题	Biochemistry & Molecular Biology; Biophysics; Crystallography
类目[WOS]	Biochemical Research Methods ; Biochemistry & Molecular Biology ; Biophysics ; Crystallography
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Crystallography
原文出处	SCI
语种	英语
WOS记录号	WOS:000277217700003
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/237726]
专题	高能物理研究所_多学科研究中心高能物理研究所_理论物理室
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liu CP,Xu R,Gao ZQ,et al. Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans[J]. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,2010,66(5):498-502.
APA	刘超培.,许锐.,高增强.,徐建华.,侯海峰.,...&Dong, YH.(2010).Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans.ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,66(5),498-502.
MLA	刘超培,et al."Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans".ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66.5(2010):498-502.