Small is Smarter: Nano MRI Contrast Agents - Advantages and Recent Achievements

CORC > 化学研究所 > 中国科学院化学研究所 > 胶体、界面与化学热力学实验室

	Small is Smarter: Nano MRI Contrast Agents - Advantages and Recent Achievements
	Gao, Zhenyu 1,2; Ma, Tiancong 2; Zhao, Enyu 2; Docter, Dominic 3; Yang, Wensheng 1; Stauber, Roland H.3; Gao, Mingyuan 2
刊名	SMALL
	2016-02-03
卷号	12 期号:5 页码:556-576
关键词	chemical synthesis magnetic nanoparticles protein coronas surface modifications tumor imaging
英文摘要	Many challenges for advanced sensitive and noninvasive clinical diagnostic imaging remain unmatched. In particular, the great potential of magnetic nano-probes is intensively discussed to further improve the performance of magnetic resonance imaging (MRI), especially for cancer diagnosis. Based on recent achievements, here the concepts of magnetic nanoparticle-based MRI contrast agents and tumor-specific imaging probes are critically summarized. Advances in their synthesis, biocompatible chemical and biofunctional surface modifications, and current strategies for further developing them into multimodality imaging probes are discussed. In addition, how engineered versus unintended surface coatings such as protein coronas affect the biocompatibility and performance of MRI nano-probes is also considered. To stimulate progress in the field, future strategies and relevant challenges that still need to be resolved in the field conclude this review.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/33815]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Jilin Univ, Coll Chem, Changchun 130012, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 3.ENT Univ Med Ctr Mainz, Dept Nanobiomed, D-55101 Mainz, Germany
推荐引用方式 GB/T 7714	Gao, Zhenyu,Ma, Tiancong,Zhao, Enyu,et al. Small is Smarter: Nano MRI Contrast Agents - Advantages and Recent Achievements[J]. SMALL,2016,12(5):556-576.
APA	Gao, Zhenyu.,Ma, Tiancong.,Zhao, Enyu.,Docter, Dominic.,Yang, Wensheng.,...&Gao, Mingyuan.(2016).Small is Smarter: Nano MRI Contrast Agents - Advantages and Recent Achievements.SMALL,12(5),556-576.
MLA	Gao, Zhenyu,et al."Small is Smarter: Nano MRI Contrast Agents - Advantages and Recent Achievements".SMALL 12.5(2016):556-576.