Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics
	Jin, Yushen1 ; Ma, Xibo4 ; Feng, Shanshan 2; Liang, Xiao4 ; Dai, Zhifei 3; Tian, Jie4 ; Yue, Xiuli 2
刊名	BIOCONJUGATE CHEMISTRY
	2015-12-01
卷号	26 期号:12 页码:2530-2541
英文摘要	Theranostic tantalum oxide nanoparticles (TaO(x)NPs) of about 40 nm were successfully developed by conjugating functional molecules including polyethylene glycol (PEG), near-infrared (NIR) fluorescent dye, doxorubicin (DOX), and hyaluronic acid (HA) onto the surface of the nanopartides (TaOx@Cy7-DOX-PEG-HA NPs) for actively targeting delivery, pH-responsive drug release, and NIR fluorescence/X-ray CT bimodal imaging. The obtained nanoagent exhibits good biocompatibility, high cumulative release rate in the acidic microenvironments, long blood circulation time, and superior tumor-targeting ability. Both in vitro and in vivo experiments show that it can serve as an excellent contrast agent to simultaneously enhance fluorescence imaging and CT imaging greatly. Most importantly, such a nanoagent could enhance the therapeutic efficacy of the tumor greatly and the tumor growth inhibition was evaluated to be 87.5%. In a word, multifunctional TaOx@Cy7-DOX-PEG-HA NPs can serve as a theranostic nanomedicine for fluorescence/X-ray CT bimodal imaging, remote-controlled therapeutics, enabling personalized detection, and treatment of cancer with high efficacy.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]	MESOPOROUS SILICA NANOPARTICLES ; RAY COMPUTED-TOMOGRAPHY ; BREAST-CANCER ; PHOTOTHERMAL THERAPY ; ANTICANCER DRUG ; CHEMOTHERAPY ; CD44 ; RELEASE ; MOLECULES ; MIGRATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000366877400027
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/10653]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China 2.Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150001, Peoples R China 3.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Jin, Yushen,Ma, Xibo,Feng, Shanshan,et al. Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics[J]. BIOCONJUGATE CHEMISTRY,2015,26(12):2530-2541.
APA	Jin, Yushen.,Ma, Xibo.,Feng, Shanshan.,Liang, Xiao.,Dai, Zhifei.,...&Yue, Xiuli.(2015).Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics.BIOCONJUGATE CHEMISTRY,26(12),2530-2541.
MLA	Jin, Yushen,et al."Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics".BIOCONJUGATE CHEMISTRY 26.12(2015):2530-2541.