Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy

	Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy
	Zhang,Yanbo; Ding,Jianxun; Sun,Diankui; Sun,Hai; Zhuang,Xiuli; Chang,Fei; Wang,Jincheng; Chen,Xuesi
刊名	materials science & engineering c-biomimetic and supramolecular systems
	2015
卷号	49 期号:4 页码:262-268
关键词	CELL LUNG-CANCER CONTROLLED-RELEASE BIOMEDICAL APPLICATIONS BLOCK-COPOLYMER DOXORUBICIN SYSTEMS HYDROGELS THERAPY VITRO NANOPARTICLES
通讯作者	ding,jx
英文摘要	in the past few decades, the in situ sustained drug delivery platforms present fascinating potential in sentinel chemotherapy of various solid tumors. in this work, doxorubicin (dox), a model antitumor drug, was loaded into the thermogel of poly(lactide-co-glycolide)-block-poly( ethylene glycol)-block-poly(lactide-co-glycolide). the moderate mechanical property of dox-loaded hydrogel was confirmed by rheological test. in vitro degradation revealed the good biodegradability of thermogel. the dox-loaded hydrogel exhibited the sustained release profiles up to 30 days without and even with elastase. the improved in vivo tumor inhibition and reduced side-effects were observed in the dox-incorporated hydrogel group compared with those in free dox group. the excellent in vivo results were further confirmed by the histopathological evaluation or terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling assay. the thermogel with great prospect may be used as an ideal controlled drug delivery platform for the designated and long-term antitumor chemotherapy. (c) 2015 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000350514100029
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67933]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang,Yanbo,Ding,Jianxun,Sun,Diankui,et al. Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy[J]. materials science & engineering c-biomimetic and supramolecular systems,2015,49(4):262-268.
APA	Zhang,Yanbo.,Ding,Jianxun.,Sun,Diankui.,Sun,Hai.,Zhuang,Xiuli.,...&Chen,Xuesi.(2015).Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy.materials science & engineering c-biomimetic and supramolecular systems,49(4),262-268.
MLA	Zhang,Yanbo,et al."Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy".materials science & engineering c-biomimetic and supramolecular systems 49.4(2015):262-268.