Novel multi-sensitive pseudo-poly(amino acid) for effective intracellular drug delivery

	Novel multi-sensitive pseudo-poly(amino acid) for effective intracellular drug delivery
	Wu,Yanjuan; Zhou,Dongfang; Qi,Yanxin; Xie,Zhigang; Chen,Xuesi; Jing,Xiabin; Huang,Yubin
刊名	rsc advances
	2015
卷号	5 期号:40 页码:31972-31983
关键词	POLYMERIC NANOPARTICLES CLICK POLYMERIZATION CANCER-CHEMOTHERAPY COPOLYMER MICELLES HYDROGEN-PEROXIDE IN-VIVO RELEASE PRODRUG REDOX DOXORUBICIN
通讯作者	huang,yb
英文摘要	novel intracellular ph, glutathione (gsh) and reactive oxygen species (ros)-responsive nanoparticles were obtained using mpeg(2k)-block-redox dual sensitive chain-block-mpeg(2k) (prdsp) which was prepared by cu(i)-catalyzed azide-alkyne cycloaddition (cuaac) click polymerization. the disulfide bond, peroxalate ester and triazole units were regularly and repeatedly arranged in the hydrophobic blocks. the disulfide bond was gsh-sensitive and the peroxalate ester structure could be disrupted by acid and hydrogen peroxide. in addition, the triazole units are capable of forming ph-responsive hydrogen bonds. dynamic light scattering (dls) and transmission electron microscopy (tem) were used to investigate the ph, gsh and ros sensitivity of the prdsp nanoparticles (nps). the results indicated that the average diameter, size distribution and morphology greatly changed upon adding gsh/h2o2 or modulating the ph. as the preloaded model anticancer drug, doxorubicin (dox) was quickly released from dox-loaded prdsp (prdsp@dox) nps by addition of 10 mm glutathione (gsh), or 10 mm h2o2 or under acidic conditions rather than under physiological conditions. confocal laser scanning microscopy (clsm) and flow cytometric analyses revealed that prdsp@dox could effectively deliver dox into the cytoplasm and nucleus of cells. therefore, prdsp nps may be a promising redox heterogeneity-sensitive carrier for efficient and controlled anticancer drug release.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67835]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wu,Yanjuan,Zhou,Dongfang,Qi,Yanxin,et al. Novel multi-sensitive pseudo-poly(amino acid) for effective intracellular drug delivery[J]. rsc advances,2015,5(40):31972-31983.
APA	Wu,Yanjuan.,Zhou,Dongfang.,Qi,Yanxin.,Xie,Zhigang.,Chen,Xuesi.,...&Huang,Yubin.(2015).Novel multi-sensitive pseudo-poly(amino acid) for effective intracellular drug delivery.rsc advances,5(40),31972-31983.
MLA	Wu,Yanjuan,et al."Novel multi-sensitive pseudo-poly(amino acid) for effective intracellular drug delivery".rsc advances 5.40(2015):31972-31983.