Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography

	Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography
	Song,Wantong; Tang,Zhaohui; Zhang,Dawei; Burton,Neal; Dirssen,Wouter; Chen,Xuesi
刊名	rsc advances
	2015
卷号	5 期号:5 页码:3807-3813
关键词	COMPUTED-TOMOGRAPHY MICELLES CANCER FLUORESCENCE MICROSCOPY CISPLATIN CARRIERS PROBES TUMORS DEEP
通讯作者	tang,zh
英文摘要	real-time and continuous monitoring of systemically administered agents is an important task in pharmaceutical development. herein, we performed a real-time continuous study of the pharmacokinetics and biodistribution of indocyanine green (icg) and liposomal indocyanine green (lipo-icg) in vivo by multispectral optoacoustic tomography (msot). by comparing the blood clearance and uptake behavior of these two icg formulations in liver, spleen, kidney and tumor, we showed that lipo-icg prolonged the retention time of icg in blood, and resulted in enhanced accumulation and retention in liver, spleen, and tumor. the results obtained from the msot test provided a comprehensive and continuous view of the metabolic behavior of the injected agents in different formulations. the results may also be helpful for understanding this new imaging technique.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67812]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Song,Wantong,Tang,Zhaohui,Zhang,Dawei,et al. Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography[J]. rsc advances,2015,5(5):3807-3813.
APA	Song,Wantong,Tang,Zhaohui,Zhang,Dawei,Burton,Neal,Dirssen,Wouter,&Chen,Xuesi.(2015).Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography.rsc advances,5(5),3807-3813.
MLA	Song,Wantong,et al."Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography".rsc advances 5.5(2015):3807-3813.