Structure modeling, synthesis and X-ray diffraction determination of an extra-large calixarene-based coordination cage and its application in drug delivery

	Structure modeling, synthesis and X-ray diffraction determination of an extra-large calixarene-based coordination cage and its application in drug delivery
	Du,Shangchao; Yu,Tang-Qing; Liao,Wuping; Hu,Chunhua
刊名	dalton transactions
	2015
卷号	44 期号:32 页码:14394-14402
关键词	METAL-ORGANIC FRAMEWORKS HOST-GUEST CHEMISTRY MOLECULAR RECOGNITION POROUS MATERIALS NANOCAPSULES ADSORPTION RELEASE CAPSULE QUANTIFICATION METALLACYCLES
通讯作者	liao,wp
英文摘要	an extra-large octahedral coordination cage (ciac-114) was designed and modeled based on co-4-p-tert-butylsulfonylcalix[4]arene (co-4-(sc4a-so2)) subunits and 4,4',4''-(benzene-1,3,5-triyl-tris(benzene-4,1-diyl))tribenzoate (bbb) ligands via the isomorphic replacement approach built from an analogous cage structure with a smaller size. x-ray crystallography revealed that the crystals obtained through solvothermal synthesis exhibited the anticipated structure. each ciac-114 cage is assembled by six tetranuclear co-4-(sc4a-so2) units as vertices, which bear a four-fold rotational symmetry, and eight tripodal bbb ligands as linkers, which hold a d-3h symmetry. among its analogues ciac-114 has the largest overall peripheral diameter of 5.4 nm and an internal cavity of 2.7 nm. after treatment by supercritical co2, a single crystal sample of ciac-114 transformed into amorphous material with the retention of the cage skeleton, which demonstrated good adsorption properties towards a small drug molecule, ibuprofen (ibu), evidenced by ir spectroscopy, h-1 nmr spectroscopy, n-2 sorption analysis, and drug release experiments. the ibu release experiment in phosphate buffered saline solution (ph = 7.4) revealed that ciac-114 exhibited a slow drug release behavior.
收录类别	SCI
语种	英语
WOS记录号	WOS:000359088200028
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/65165]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Du,Shangchao,Yu,Tang-Qing,Liao,Wuping,et al. Structure modeling, synthesis and X-ray diffraction determination of an extra-large calixarene-based coordination cage and its application in drug delivery[J]. dalton transactions,2015,44(32):14394-14402.
APA	Du,Shangchao,Yu,Tang-Qing,Liao,Wuping,&Hu,Chunhua.(2015).Structure modeling, synthesis and X-ray diffraction determination of an extra-large calixarene-based coordination cage and its application in drug delivery.dalton transactions,44(32),14394-14402.
MLA	Du,Shangchao,et al."Structure modeling, synthesis and X-ray diffraction determination of an extra-large calixarene-based coordination cage and its application in drug delivery".dalton transactions 44.32(2015):14394-14402.