A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols

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	A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols
	Pan, Bing 1; Liu, Bo 1; Yue, Erlin 2; Liu QB(刘庆彬)1; Yang, Xinzheng 2; Wang, Zheng 1,2; Sun WH(孙文华)2,3
刊名	ACS Catalysis
	2016
卷号	6 期号:2 页码:1247-1253
关键词	ruthenium catalyst coupling cyclization N-heterocyclic compound AD reaction high efficiency
ISSN号	2155-5435
通讯作者	刘庆彬 ; 孙文华
英文摘要	The ruthenium complex (8-(2-diphenylphosphinoethyl)aminotrihydroquinolinyl)(carbonyl)(hydrido)ruthenium chloride exhibited extremely high efficiency toward the coupling cyclization of γ-amino alcohols with secondary alcohols. The corresponding products, pyridine or quinoline derivatives, are obtained in good to high isolated yields. On comparison with literature catalysts whose noble-metal loading with respect to γ-amino alcohols reached 0.5–1.0 mol % for Ru and a record lowest of 0.04 mol % for Ir, the current catalyst achieves the same efficiency with a loading of 0.025 mol % for Ru. The mechanism of acceptorless dehydrogenative condensation (ADC) was proposed on the basis of DFT calculations; in addition, the reactive intermediates were determined by GC-MS, NMR, and single-crystal X-ray diffraction. The catalytic process is potentially suitable for industrial applications.
学科主题	物理化学与绿色催化
收录类别	SCI
资助信息	the National Natural Science Foundation of China (Nos. 21476060;21374123;U1362204;21373228);the Nature Science Foundation of Hebei Province (No. B2014205049), China
语种	英语
WOS记录号	WOS:000369774900086
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/19732]
专题	兰州化学物理研究所_OSSO国家重点实验室
作者单位	1.Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Pan, Bing,Liu, Bo,Yue, Erlin,et al. A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols[J]. ACS Catalysis,2016,6(2):1247-1253.
APA	Pan, Bing.,Liu, Bo.,Yue, Erlin.,Liu QB.,Yang, Xinzheng.,...&Sun WH.(2016).A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols.ACS Catalysis,6(2),1247-1253.
MLA	Pan, Bing,et al."A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols".ACS Catalysis 6.2(2016):1247-1253.