Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles

	Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles
	Yan, Hao; Wang, Haolong; Li, Xincheng; Xin, Xiaoyi; Wang, Chunxiang; Wan, Boshun
刊名	angewandte chemie-international edition
	2015-09-01
卷号	54 期号:36 页码:10613-10617
关键词	alkynes CH activation indoles nitrones rhodium
英文摘要	the direct ch annulation of anilines or related compounds with internal alkynes provides straightforward access to 2,3-disubstituted indole products. however, this transformation proceeds with poor regioselectivity in the synthesis of unsymmetrically 2,3-diaryl substituted indoles. herein, we report the rhodium(iii)-catalyzed ch annulation of nitrones with symmetrical diaryl alkynes as an alternative method to prepare 2,3-diaryl-substituted n-unprotected indoles with two different aryl groups. one of the aryl substituents is derived from nc-aryl ring of the nitrone and the other from the alkyne substrate, thus providing the indole products with exclusive regioselectivity.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	carbon triple bond ; n-aryl enamines ; nonrearranged monoterpenoid unit ; 3,4-fused tricyclic indoles ; 2,3-disubstituted indoles ; h activation ; efficient synthesis ; internal alkynes ; oxidative cyclization ; molecular-oxygen
收录类别	SCI
语种	英语
WOS记录号	WOS:000360312800040
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146494]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Yan, Hao,Wang, Haolong,Li, Xincheng,et al. Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles[J]. angewandte chemie-international edition,2015,54(36):10613-10617.
APA	Yan, Hao,Wang, Haolong,Li, Xincheng,Xin, Xiaoyi,Wang, Chunxiang,&Wan, Boshun.(2015).Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles.angewandte chemie-international edition,54(36),10613-10617.
MLA	Yan, Hao,et al."Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles".angewandte chemie-international edition 54.36(2015):10613-10617.