Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice

	Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice
	Song, Xiaojie 1,2; Wu, Hao 1,2; Li, Shen 1,2; Wang, Yanfang 1,2; Ma, Xiaojun 1; Tan, Mingqian 1
刊名	biomacromolecules
	2015-07-01
卷号	16 期号:7 页码:2080-2090
英文摘要	nanocarriers play an important role in improving the photo- and thermal-stability of photosensitizers to gain better pharmacokinetics behavior in tumor photothermal therapy. herein, pegylated chitosan (cg-peg; peg: polyethylene glycol) nanoparticles with ultrasmall size (similar to 5 nm), were prepared through a water-in-oil reverse microemulsion method using genipin as a cross-linker. particle size and zeta-potential can be tuned by varying the molar ratio between chitosan amino groups and genipin. cg-peg-icg (icg: indocyanine green) nanoparticles were fabricated by adding icg to cg-peg aqueous solution through a self-assembly method via electrostatic interaction. the resultant cg-peg-icg nanoparticles exhibited improved photo- and thermal-stability, good biocompatibility, and low toxicity. when irradiated with a laser, the cells incubated with cg-peg-icg nanoparticles showed very low cell viability (15%), indicating the cg-peg-icg nanoparticles possess high in vitro photothermal toxicity. moreover, the cg-peg nanocarriers can significantly alter the biodistribution and prolong the retention time of icg in the mice body after intravenous injection. in vivo photothermal study of tumors injected with cg-peg-icg nanoparticles containing icg at a concentration greater than 100 mu g.ml(-1) (100 mu l) induced irreversible tissue damage. the growth of u87 tumors was dramatically inhibited by cg-peg-icg nanoparticles, demonstrating that the cg-peg nanoparticles may act as potential icg nanocarriers for effective in vivo tumor photothermal therapy.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemistry & molecular biology ; chemistry, organic ; polymer science
研究领域[WOS]	biochemistry & molecular biology ; chemistry ; polymer science
关键词[WOS]	indocyanine-green ; silica nanoparticles ; drug-delivery ; in-vitro ; peg ; biodistribution ; hydrogels ; release ; system
收录类别	SCI
语种	英语
WOS记录号	WOS:000358026400020
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146390]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Song, Xiaojie,Wu, Hao,Li, Shen,et al. Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice[J]. biomacromolecules,2015,16(7):2080-2090.
APA	Song, Xiaojie,Wu, Hao,Li, Shen,Wang, Yanfang,Ma, Xiaojun,&Tan, Mingqian.(2015).Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice.biomacromolecules,16(7),2080-2090.
MLA	Song, Xiaojie,et al."Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice".biomacromolecules 16.7(2015):2080-2090.