Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae

	Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
	Zhang, Jingxiao 1; Li, Yan 1; Chen, Su-Shing 2,3; Zhang, Lilei 4; Wang, Jinghui 1; Yang, Yinfeng 1; Zhang, Shuwei 1; Pan, Yanqiu 1; Wang, Yonghua 5; Yang, Ling 6
刊名	international journal of molecular sciences
	2015-02-01
卷号	16 期号:2 页码:2913-2941
英文摘要	inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb folium eriobotryae, a widely used clinical anti-inflammatory botanic drug. the results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. in addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially cox2, alox5, pparg, tnf and rela that are mainly involved in the mitogen-activated protein kinase (mapk) signaling pathway, the rheumatoid arthritis pathway and nf-kappa b signaling pathway. all these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemistry & molecular biology ; chemistry, multidisciplinary
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	nf-kappa-b ; traditional chinese medicine ; japonica thunb. lindl. ; inflammatory diseases ; chlorogenic acid ; drug discovery ; ursolic acid ; oral bioavailability ; therapeutic targets ; chronic-bronchitis
收录类别	SCI
语种	英语
WOS记录号	WOS:000350333600038
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146032]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Univ Technol, Key Lab Ind Ecol & Environm Engn MOE, Fac Chem Environm & Biol Sci & Technol, Dalian 116024, Peoples R China 2.Univ Florida, Syst Biol Lab, Gainesville, FL 32608 USA 3.Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32608 USA 4.Hubei Univ Nationalities, Sch Chem & Environm Engn, Enshi 445000, Peoples R China 5.Northwest A&F Univ, Coll Life Sci, Ctr Bioinformat, Yangling 712100, Peoples R China 6.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jingxiao,Li, Yan,Chen, Su-Shing,et al. Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae[J]. international journal of molecular sciences,2015,16(2):2913-2941.
APA	Zhang, Jingxiao.,Li, Yan.,Chen, Su-Shing.,Zhang, Lilei.,Wang, Jinghui.,...&Yang, Ling.(2015).Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae.international journal of molecular sciences,16(2),2913-2941.
MLA	Zhang, Jingxiao,et al."Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae".international journal of molecular sciences 16.2(2015):2913-2941.