Species-Associated Differences in the Inhibition of Propofol Glucuronidation by Magnolol

	Species-Associated Differences in the Inhibition of Propofol Glucuronidation by Magnolol
	Yang, Lu 1; Zhu, Liangliang 2; Ge, Guangbo 4; Xiao, Ling 3; Wu, Yan 2; Liang, Sicheng 4; Cao, Yunfeng 4; Yang, Ling 4; Wang, Dong 1
刊名	journal of the american association for laboratory animal science
	2014-07-01
卷号	53 期号:4 页码:408-411
英文摘要	magnolol, a major active constituent in herbal medicine, potently inhibits propofol glucuronidation in human liver microsomes, with inhibition constants in the nanomolar range. this study was conducted to investigate magnolol-induced inhibition of propofol glucuronidation in liver microsomes from swiss-hauschka mice, sprague-dawley rats, chinese bama pigs, and cynomolgus macaques. results indicated that magnolol (10 mu m) inhibited propofol glucuronidation in liver microsomes from bama pigs and cynomolgus macaques but not in those from mice or rats. data from liver microsomes from bama pigs indicated a competitive inhibition mechanism, with a k-i of 1.7 mu m. in contrast to that of pig liver microsomes, the inhibition of microsomes from cynomolgus macaques followed a noncompetitive mechanism, with a k-i of 3.4 mu m. in summary, this study indicates that magnolol-induced inhibition of propofol glucuronidation varies substantially among species, and the k-i values determined by using liver microsomes from various experimental animal species far exceed that for human liver microsomes. the inhibition of propofol glucuronidation by magnolol in liver microsomes from all animal species tested was significantly lower than the inhibition previously demonstrated in human liver microsomes. hepatic microsomes from swiss-hauschka mice, sprague-dawley rats, chinese bama pigs, and cynomolgus macaques are not effective models of the inhibition of glucuronidation induced by magnolol in humans.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	veterinary sciences ; zoology
研究领域[WOS]	veterinary sciences ; zoology
关键词[WOS]	messenger-rna expression ; udp-glucuronosyltransferases ; microsomes ; metabolism ; isoforms ; liver ; mice
收录类别	SCI
语种	英语
WOS记录号	WOS:000339231600012
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/145697]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian, Peoples R China 2.Anqing Normal Univ, Sch Life Sci, Anqing, Peoples R China 3.Anqing Normal Univ, Sch Resources & Environm, Anqing, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Yang, Lu,Zhu, Liangliang,Ge, Guangbo,et al. Species-Associated Differences in the Inhibition of Propofol Glucuronidation by Magnolol[J]. journal of the american association for laboratory animal science,2014,53(4):408-411.
APA	Yang, Lu.,Zhu, Liangliang.,Ge, Guangbo.,Xiao, Ling.,Wu, Yan.,...&Wang, Dong.(2014).Species-Associated Differences in the Inhibition of Propofol Glucuronidation by Magnolol.journal of the american association for laboratory animal science,53(4),408-411.
MLA	Yang, Lu,et al."Species-Associated Differences in the Inhibition of Propofol Glucuronidation by Magnolol".journal of the american association for laboratory animal science 53.4(2014):408-411.