One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer

	One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer
	Zheng,Min; Liu,Shi; Guan,Xingang; Xie,Zhigang
刊名	acs applied materials & interfaces
	2015
卷号	7 期号:40 页码:22181-22187
关键词	METAL-ORGANIC FRAMEWORKS COORDINATION POLYMERS CO2 CAPTURE NANOPARTICLES CELLS RELEASE ENCAPSULATION PH DELIVERY STORAGE
通讯作者	xie,zg
英文摘要	a straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (ccm)-loaded nanoscale zeolitic imidazolate framework-8 (ccm@nzif-8) nanopartides (nps). the as-synthesized ccm@nzif-8 nps possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. confocal laser scanning microscopy and cytotoxicity experiments reveal that nzif-8 based nanocarriers promote the cellular uptake of ccm and result in higher cytotoxicity of ccm@nzif-8 than that of free ccm toward hela cells. the in vivo anticancer experiments indicate that ccm@nzif-8 nps exhibit much higher antitumor efficacy than free ccm. this work highlights the potential of using nanoscale metal organic framworks (nmofs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment.
收录类别	SCI
语种	英语
WOS记录号	WOS:000363001500009
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64755]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zheng,Min,Liu,Shi,Guan,Xingang,et al. One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer[J]. acs applied materials & interfaces,2015,7(40):22181-22187.
APA	Zheng,Min,Liu,Shi,Guan,Xingang,&Xie,Zhigang.(2015).One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer.acs applied materials & interfaces,7(40),22181-22187.
MLA	Zheng,Min,et al."One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer".acs applied materials & interfaces 7.40(2015):22181-22187.