Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose

	Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose
	Wang, Lu-Liang 1,2,3,4,5; Qiao, Juan 3,4,5; Qi, Li 3,4,5; Xu, Xiao-Zhe 6; Li, Dan 1,2
刊名	SCIENCE CHINA-CHEMISTRY
	2015-09-01
卷号	58 期号:9 页码:1508-1514
关键词	AuNCs Ovalbumin GOx glucose fluorescence
英文摘要	Protein protected gold nanoclusters have outstanding physical and chemical properties that make them excellent scaffolds for the construction of novel chemical and biological probes. In this study, a simple one-pot synthesis method was proposed for the preparation of fluorescent probes based on ovalbumin-stabilized gold nanoclusters. This strategy allowed the generation of water-soluble gold nanoclusters within 5 min. The as-prepared fluorescent probe exhibited a red fluorescence emission at 625 nm, and good thermostability. The fluorescent probe was applied to measure glucose concentrations based on the hydrogen peroxide-induced fluorescence quenching principle, and showed favorable biocompatibility, high sensitivity and good selectivity. As a result of the advantageous properties and performance of this fluorescent probe, the present assay allowed for the selective determination of glucose in the range of 5.0x10(-6) to 10.0x10(-3) mol/L with a detection limit of 1.0x10(-6) mol/L. Moreover, the glucose content in urinary samples was analyzed using the constructed fluorescent probe: this indicated the potential of the fluorescent gold nanoclusters for applications in biological and clinical diagnosis and therapy.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/27645]
专题	化学研究所_活体分析化学实验室
作者单位	1.Shantou Univ, Dept Chem, Shantou 515063, Peoples R China 2.Shantou Univ, Res Inst Biomed & Adv Mat, Shantou 515063, Peoples R China 3.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 6.Tianjin Normal Univ, Coll Chem, Tianjin 300387, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lu-Liang,Qiao, Juan,Qi, Li,et al. Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose[J]. SCIENCE CHINA-CHEMISTRY,2015,58(9):1508-1514.
APA	Wang, Lu-Liang,Qiao, Juan,Qi, Li,Xu, Xiao-Zhe,&Li, Dan.(2015).Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose.SCIENCE CHINA-CHEMISTRY,58(9),1508-1514.
MLA	Wang, Lu-Liang,et al."Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose".SCIENCE CHINA-CHEMISTRY 58.9(2015):1508-1514.