Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy

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	Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy
	Liu, Kai 1,2; Xing, Ruirui 1; Zou, Qianli 1,3; Ma, Guanghui 1; Mohwald, Helmuth 3; Yan, Xuehai 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2016-02-24
卷号	55 期号:9 页码:3036-3039
关键词	cooperative self-assembly nanodrugs peptides photodynamic therapy photosensitizers
ISSN号	1433-7851
通讯作者	Yan, XH (reprint author), Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China.
英文摘要	Peptide-tuned self-assembly of functional components offers a strategy towards improved properties and unique functions of materials, but the requirement of many different functions and a lack of understanding of complex structures present a high barrier for applications. Herein, we report a photosensitive drug delivery system for photodynamic therapy (PDT) by a simple dipeptide- or amphiphilic amino-acid-tuned self-assembly of photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including tunable size, high loading efficiency, and on-demand drug release responding to pH, surfactant, and enzyme stimuli, as well as preferable cellular uptake and biodistribution. These features result in greatly enhanced PDT efficacy invitro and invivo, leading to almost complete tumor eradication in mice receiving a single drug dose and a single exposure to light.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	CANCER-TREATMENT ; IN-VITRO ; NANOPARTICLES ; DELIVERY ; AGENTS ; INTERNALIZATION ; PORPHYRINS ; EFFICIENCY ; SYSTEMS ; GLYCOL
收录类别	SCI
语种	英语
WOS记录号	WOS:000370656200008
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/20625]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Max Planck Inst Colloids & Interfaces, Muhlenberg 1, D-14476 Potsdam, Germany
推荐引用方式 GB/T 7714	Liu, Kai,Xing, Ruirui,Zou, Qianli,et al. Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(9):3036-3039.
APA	Liu, Kai,Xing, Ruirui,Zou, Qianli,Ma, Guanghui,Mohwald, Helmuth,&Yan, Xuehai.(2016).Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(9),3036-3039.
MLA	Liu, Kai,et al."Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.9(2016):3036-3039.