One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy

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	One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy
	Zhou, Chao 1,2; Abbas, Manzar 2; Zhang, Min 3; Zou, Qianli 2; Shen, Guizhi 2; Chen, Chengjun 2; Peng, Hongshang 1; Yan, Xuehai 2
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2015-12-01
卷号	15 期号:12 页码:10141-10148
关键词	Hydrophobic Photosensitizers Nanoparticles Polyelectrolyte Coating Drug Delivery Photodynamic Therapy
ISSN号	1533-4880
英文摘要	Nanoengineering of anticancer therapeutic drugs including photosensitizers is highly desired and extremely required for improved therapeutic efficacy. It remains a formidable challenge to achieve nanostructured colloidal particles directly starting from hydrophobic drugs due to their hydrophobic nature and ready aggregation in aqueous ambient. In this work, we report a facile method for a one-pot preparation of hydrophobic photosensitizer nanoparticles by coating with different types of polyelectrolyte as stabilizing agents. Regardless of negatively or positively charged polyelectrolyte used, including Poly-L-lysine (PLL, MW = 15 k-30 k), PLL (MW = 30 k-70 k), heparin, and hyaluronic acid (HA), the hydrophobic photosensitizer BDEA (2,5-Bis(4-(diethylamino)benzylidene)cyclopentanone) as a model drug can be readily manipulated into stable and well-dispersed nanoparticles with size of average 120 nm. Stabilization presumably contributes to electrostatic repulsion of the adsorbed polyelectrolyte layer onto nanoparticles. Their anticancer activity against the HeLa cell line shows that the endocytic internalization of these nanosystems is associated with antiproliferative effects after irradiation with visible light. The one-step preparation strategy may be an alternative approach for the design of nano-formulations of hydrophobic photosensitive drugs, presenting a potential for photodynamic antitumor therapy.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	2-PHOTON ABSORPTION ; CANCER ; PORPHYRIN ; DELIVERY ; MICROCAPSULES ; NANOPARTICLES ; NANOSHELLS ; STRATEGIES ; SPHERES ; DESIGN
收录类别	SCI
语种	英语
WOS记录号	WOS:000365555000108
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/19905]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Beijing Jiaotong Univ, Inst Optoelect Technol, Key Lab Luminescence & Opt Informat, Minist Educ, Beijing 100044, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.China Food & Drug Adm, Ctr Drug Evaluat, Beijing 100038, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Chao,Abbas, Manzar,Zhang, Min,et al. One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2015,15(12):10141-10148.
APA	Zhou, Chao.,Abbas, Manzar.,Zhang, Min.,Zou, Qianli.,Shen, Guizhi.,...&Yan, Xuehai.(2015).One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,15(12),10141-10148.
MLA	Zhou, Chao,et al."One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15.12(2015):10141-10148.