The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model

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	The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model
	Zhang, Leilei 1; Li, Zhi 2; Chen, Jie1 ; Li, Xinying1 ; Zhang, Jianxin1 ; Belsky, Jay 2
刊名	JOURNAL OF YOUTH AND ADOLESCENCE
	2016-03-01
卷号	45 期号:3 页码:471-483
关键词	Adolescent depressive symptoms BDNF Val66Met polymorphism Differential susceptibility Gene-environment interaction Maternal parenting
ISSN号	0047-2891
英文摘要	Although depressive symptoms are common during adolescence, little research has examined gene-environment interaction on youth depression. This study chose the brain-derived neurotrophic factor (BDNF) gene, tested the interaction between a functional polymorphism resulting amino acid substitution of valine (Val) to methionine (Met) in the proBDNF protein at codon 66 (Val66Met), and maternal parenting on youth depressive symptoms in a sample of 780 community adolescents of Chinese Han ethnicity (aged 11-17, M = 13.6, 51.3 % females). Participants reported their depressive symptoms and perceived maternal parenting. Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms. Confirmatory model evaluation indicated that the interaction effect involving warmth-reasoning conformed to the differential-susceptibility rather than diathesis-stress model of person-X-environment interaction. Thus, Val carriers experienced less depressive symptoms than Met homozygotes when mothering was more positive but more symptoms when mothering was less positive. The findings provided evidence in support of the differential susceptibility hypothesis of youth depressive symptoms and shed light on the importance of examining the gene-environment interaction from a developmental perspective.
WOS标题词	Social Sciences
类目[WOS]	Psychology, Developmental
研究领域[WOS]	Psychology
关键词[WOS]	GENE-ENVIRONMENT INTERACTION ; STRESSFUL LIFE EVENTS ; HPA-AXIS REACTIVITY ; CONDUCT PROBLEMS ; MAJOR DEPRESSION ; MOLECULAR-GENETICS ; MISSING DATA ; METAANALYSIS ; CHILDREN ; BEHAVIORS
收录类别	SSCI
语种	英语
WOS记录号	WOS:000370072000004
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/19572]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Calif Davis, Dept Human Ecol, Davis, CA 95616 USA
推荐引用方式 GB/T 7714	Zhang, Leilei,Li, Zhi,Chen, Jie,et al. The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model[J]. JOURNAL OF YOUTH AND ADOLESCENCE,2016,45(3):471-483.
APA	Zhang, Leilei,Li, Zhi,Chen, Jie,Li, Xinying,Zhang, Jianxin,&Belsky, Jay.(2016).The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model.JOURNAL OF YOUTH AND ADOLESCENCE,45(3),471-483.
MLA	Zhang, Leilei,et al."The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model".JOURNAL OF YOUTH AND ADOLESCENCE 45.3(2016):471-483.