Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus

	Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus
	Chen HQ(陈汉清); Gao D(高迪); Wang B(汪冰); Chen, HQ; Gao, D; Wang, B; Zhao, RF; Guan, M; Zheng, LN; Zhou, XY
刊名	NANOTECHNOLOGY
	2014
卷号	25 期号:16 页码:165101
关键词	graphene oxide gut bacteria proliferation B. adolescentis antagonistic effect
英文摘要	The impact of the gut microbiota on human health is widely perceived as the most exciting advancement in biomedicine. The gut microbiota has been known to play a crucial role in defining states of human health and diseases, and thus becomes a potential new territory for drug targeting. Herein, graphene oxide ( GO) interaction with five common human gut bacteria, B. adolescentis, L. acidophilus, E. coli, E. faecalis, and S. aureus, was studied. It was shown that, in bacterial media, GO sheets were able to form effective, anaerobic membrane scaffolds that enhanced the antagonistic activity of B. adolescentis against the pathogens E. coli and S. aureus. Data obtained using bacterial growth measurements, colony counting and 16S rRNA gene sequencing consistently indicated that GO sheets promoted proliferation of gut bacteria, particularly for B. adolescentis. Scanning electron microscopy, atomic force microscopy images, and membrane potential measurements showed that cell membranes maintained their integrity and that no observable variations in cell morphology were induced after interaction with GO sheets, indicating good biocompatibility of GO. These results suggest the possibility of using GO sheets as efficient drug carriers in therapeutic applications to treat diseases related to the gut microbiota.
学科主题	Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000333814700001
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/225202]
专题	高能物理研究所_院士高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Chen HQ,Gao D,Wang B,et al. Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus[J]. NANOTECHNOLOGY,2014,25(16):165101.
APA	陈汉清.,高迪.,汪冰.,Chen, HQ.,Gao, D.,...&丰伟悦.(2014).Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus.NANOTECHNOLOGY,25(16),165101.
MLA	陈汉清,et al."Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus".NANOTECHNOLOGY 25.16(2014):165101.