Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder

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	Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder
	Ye T(叶婷); Ye, T; Nie BB(聂彬彬); Peng, J; Nie, BB; Gao, J; Liu, JT; Li, Y; Wang, G; Ma, X
刊名	EUROPEAN JOURNAL OF RADIOLOGY
	2012
卷号	81 期号:12 页码:4035-4040
关键词	Major depressive disorder Functional connectivity Dorsolateral prefrontal cortex Voxel-based morphometry
英文摘要	Background: The aim of this study was to investigate resting-state functional connectivity alteration of the right dorsolateral prefrontal cortex (DLPFC) in patients with first-episode major depressive disorder (MDD). Methods: Twenty-two first-episode MDD patients and thirty age-, gender-and education-matched healthy control subjects were enrolled. Rest state functional magnetic resonance images and structure magnetic resonance images were scanned. The functional connectivity analysis was done based on the result of voxel-based morphometry (VBM). And the right DLPFC was chosen as the seed region of interests (ROI), as its gray matter density (GMD) decreased in the MDD patients compared with controls and its GMD values were negative correlation with the Hamilton Depression Rating Scale (HDRS) scores. Results: Compared to healthy controls, the MDD patients showed increased functional connectivity with right the DLPFC in the left dorsal anterior cingulate cortex (ACC), left parahippocampal gyrus (PHG), thalamus and precentral gyrus. In contrast, there were decreased functional connectivity between the right DLPFC and right parietal lobe. Conclusions: By applying the VBM results to the functional connectivity analysis, the study suggested that abnormality of GMD in right DLPFC might be related to the functional connectivity alteration in the pathophysiology of MDD, which might be useful in further characterizing structure-function relations in this disorder. (C) 2012 Published by Elsevier Ireland Ltd.
学科主题	Radiology, Nuclear Medicine & Medical Imaging
收录类别	SCI
WOS记录号	WOS:000311340800055
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224249]
专题	高能物理研究所_核技术应用研究中心
推荐引用方式 GB/T 7714	Ye T,Ye, T,Nie BB,et al. Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder[J]. EUROPEAN JOURNAL OF RADIOLOGY,2012,81(12):4035-4040.
APA	叶婷.,Ye, T.,聂彬彬.,Peng, J.,Nie, BB.,...&单保慈.(2012).Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder.EUROPEAN JOURNAL OF RADIOLOGY,81(12),4035-4040.
MLA	叶婷,et al."Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder".EUROPEAN JOURNAL OF RADIOLOGY 81.12(2012):4035-4040.