Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy

	Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy
	Zhang TC(张天冲); Yi FT(伊福廷); Wang B(王波); Liu J(刘静); Zhang XS(张新帅); Sun GJ(孙钢杰); Zhang, X; Tian, G; Yin, WY; Wang, LM
刊名	ADVANCED FUNCTIONAL MATERIALS
	2015
卷号	25 期号:20 页码:3049-3056
关键词	upconversion nanoparticles nitric oxide energy transfer dose-dependent biological effect multi-drug resistance reversal
通讯作者	田甘 ; 谷战军 ; 赵宇亮
英文摘要	NaYbF4:Tm@NaYF4:Yb/Er upconversion nanoparticles are synthesized and then integrated with light-sensitive nitric oxide (NO) donors (Roussin's black salt) to construct a novel near-infrared (NIR)-triggered on-demand NO delivery platform. This nanocompound can absorb 980 nm NIR photons, convert them into higher energy photons and then transfer the energy to the NO donors, resulting in an efficient release of NO. By manipulating the output power of the 980-nm NIR light, NO-concentration-dependent biological effects for cancer therapy can be fine-tuned, which is investigated and confirmed in vitro. High concentrations of NO can directly kill cancer cells and low concentrations of NO can act as a potent P-glycoprotein (P-gp) modulator to overcome multi-drug resistance (MDR) if combined with chemotherapy.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
收录类别	SCI ; EI ; CA
WOS记录号	WOS:000355125400011
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228483]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Zhang TC,Yi FT,Wang B,et al. Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(20):3049-3056.
APA	张天冲.,伊福廷.,王波.,刘静.,张新帅.,...&Zhao, YL.(2015).Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy.ADVANCED FUNCTIONAL MATERIALS,25(20),3049-3056.
MLA	张天冲,et al."Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy".ADVANCED FUNCTIONAL MATERIALS 25.20(2015):3049-3056.