Effects of lanthanum on composition, crystal size, and lattice structure of femur bone mineral of Wistar rats

	Effects of lanthanum on composition, crystal size, and lattice structure of femur bone mineral of Wistar rats
	Huang, J; Zhang, TL; Xu, SJ; Li, RC; Wang, K; Zhang, J; Xie, YN; Zhang J(张静); Xie YN(谢亚宁)
刊名	CALCIFIED TISSUE INTERNATIONAL
	2006
卷号	78 期号:4 页码:#REF!
关键词	lanthanum bone mineral crystal size lattice structure rat
通讯作者	Zhang, TL (reprint author), Capital Univ Med Sci, Sch Pharmaceut Sci, 10 Xitoutiao, Beijing 100054, Peoples R China.
英文摘要	The application of lanthanum (La) in industry, medicine, and agriculture may cause accumulation of the element in human body. This article examines the effects of La on the femur bone mineral of male Wistar rats after administration of La(NO3)(3) by gavage at the dose of 2.0 mg La(NO3)(3) center dot kg(-1) center dot day(-1) over a 6-month period. Chemical analysis confirmed La accumulation in bone and loss in bone mineral. Thermogravimetric analysis showed a decrease in the mineral-to-matrix ratio and an increase in carbonate content. Fourier-transform infrared spectrometry revealed elevation in the contents of labile carbonate and acidic phosphate. The synchrotron radiation small-angle X-ray scattering study presented a smaller mean thickness of the mineral crystals in the bone of La-treated rats. The synchrotron radiation-extended X-ray absorption fine structure analysis indicated that the La treatment resulted in a lowered disorder in the crystals. The smaller size, more adsorbed labile carbonate, and more acidic phosphate made the bone mineral easier to dissolve, as revealed in the kinetic measurement of bone demineralization. These findings suggest that La retards bone maturation of rats.
学科主题	Endocrinology & Metabolism
类目[WOS]	Endocrinology & Metabolism
收录类别	SCI
WOS记录号	WOS:000236751000007
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/227147]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Huang, J,Zhang, TL,Xu, SJ,et al. Effects of lanthanum on composition, crystal size, and lattice structure of femur bone mineral of Wistar rats[J]. CALCIFIED TISSUE INTERNATIONAL,2006,78(4):#REF!.
APA	Huang, J.,Zhang, TL.,Xu, SJ.,Li, RC.,Wang, K.,...&谢亚宁.(2006).Effects of lanthanum on composition, crystal size, and lattice structure of femur bone mineral of Wistar rats.CALCIFIED TISSUE INTERNATIONAL,78(4),#REF!.
MLA	Huang, J,et al."Effects of lanthanum on composition, crystal size, and lattice structure of femur bone mineral of Wistar rats".CALCIFIED TISSUE INTERNATIONAL 78.4(2006):#REF!.