Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans | |
Liu Y(刘颖); Gao ZQ(高增强); Liu CP(刘超培); Xu JH(徐建华); Dong YH(董宇辉); Liu, Y; Gao, ZQ; Liu, CP; Xu, JH; Li, LF | |
刊名 | ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS |
2011 | |
卷号 | 67期号:2页码:#REF! |
通讯作者 | Dong, YH (reprint author), Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China. |
英文摘要 | Streptococcus mutans is one of the pathogenic species involved in dental caries, especially in the initiation and development stages. Here, the crystal structure of SMU.595, a putative dihydroorotate dehydrogenase ( DHOD) from S. mutans, is reported at 2.4 angstrom resolution. DHOD is a flavin mononucleotide-containing enzyme which catalyzes the oxidation of L-dihydroorotate to orotate, which is the fourth step and the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. The reductive lysine-methylation procedure was applied in order to improve the diffraction qualities of the crystals. Analysis of the S. mutans DHOD crystal structure shows that this enzyme is a class 1A DHOD and also suggests potential sites that could be exploited for the design of highly specific inhibitors using the structure-based chemotherapeutic design technique. |
学科主题 | Biochemistry & Molecular Biology; Biophysics; Crystallography |
类目[WOS] | Biochemical Research Methods ; Biochemistry & Molecular Biology ; Biophysics ; Crystallography |
收录类别 | SCI |
WOS记录号 | WOS:000287030600002 |
公开日期 | 2016-05-03 |
内容类型 | 期刊论文 |
源URL | [http://ir.ihep.ac.cn/handle/311005/226754] |
专题 | 中国科学院高能物理研究所 |
推荐引用方式 GB/T 7714 | Liu Y,Gao ZQ,Liu CP,et al. Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans[J]. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,2011,67(2):#REF!. |
APA | 刘颖.,高增强.,刘超培.,徐建华.,董宇辉.,...&Dong, YH.(2011).Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,67(2),#REF!. |
MLA | 刘颖,et al."Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans".ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 67.2(2011):#REF!. |
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