Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy

	Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy
	Zheng XP(郑晓鹏); Zhou LJ(周亮君); Yin WY(尹文艳); Zheng, XP; Zhou, LJ; Bu, Y; Yin, WY; Hu, ZB; Li, M; Gu, ZJ
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2014
卷号	2 期号:38 页码:6508-6516
英文摘要	The combined use nanotechnology and medical technologies holds great promise for the development and improvement of various theranostic media. Here, based on a facile hydrothermal method, polyethyleneimine (PEI) functionalized YbPO4: Er up-conversion porous nanospheres (UCPSs) were fabricated, which combined the capabilities of up-conversion luminescence (UCL)/X-ray computed tomography (CT) bimodal imaging and drug delivery. The resulting hydrophilic PEI functionalized YbPO4: Er UCPSs (PEI-UCPSs) showed uniform morphology and high crystallinity. Moreover, PEI-UCPSs possessed high drug loading capacity because of their large specific surface area, which was confirmed by the Brunauer-Emmett-Teller (BET) experiment. Cellular experiments indicated that the PEI-UCPSs had low cytotoxicity and confirmed the performance of the pH-mediated cancer targeting of PEI-UCPSs@DOX. Importantly, because of the ideal UCL property and high CT contrast both in vitro and in vivo, YbPO4: Er PEI-UCPSs could be used as an optical probe and a contrast agent for optical and CT imaging, forming a promising platform for simultaneous bioimaging and drug delivery.
学科主题	Materials Science
收录类别	SCI
WOS记录号	WOS:000342079900008
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/225113]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Zheng XP,Zhou LJ,Yin WY,et al. Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(38):6508-6516.
APA	郑晓鹏.,周亮君.,尹文艳.,Zheng, XP.,Zhou, LJ.,...&赵宇亮.(2014).Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy.JOURNAL OF MATERIALS CHEMISTRY B,2(38),6508-6516.
MLA	郑晓鹏,et al."Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy".JOURNAL OF MATERIALS CHEMISTRY B 2.38(2014):6508-6516.