A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells

	A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells
	Zhang, XY; He X(何潇); Li YY(李媛媛); Zhang ZY(张智勇); 马宇辉;He, X; Li, YY; Zhang, ZY; Ma, YH; Li, FM; Liu, JM
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2013
卷号	13 期号:8 页码:5254-5259
关键词	Carbon Dots Cytotoxicity Membrane Injury Oxidative Damage
英文摘要	The labeling of living cells with carbon nanoparticles has been increasingly studied both in vivo and in vitro, but concerns about the potential cytotoxicity of these nanoprobes are also increasing. In this study, the fluorescent carbon dots (CDs) without surface modification was synthesized and evaluated for its cytotoxicity. Indicators including cell viability, total reactive oxygen species (ROS), glutathione, malondialdehyde and lactate dehydrogenase were assessed using human bronchial epithelial (16HBE) cell line. Our results showed that CDs preferred to locate on the surface of cells, which significantly increased the membrane permeability of 16HBE cells. CDs exposure could further induce oxidative stress, exhaust the antioxidant defenses of cells and finally lead to decreased cell viability. Therefore, surface modification of CDs is needed to minimize its cytotoxicity. The present work is useful for the development of new strategies towards the in vitro and in vivo applications of CDs for optical imaging and drug delivery.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000320632200005
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224256]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Zhang, XY,He X,Li YY,et al. A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(8):5254-5259.
APA	Zhang, XY.,何潇.,李媛媛.,张智勇.,马宇辉；He, X.,...&Liu, JM.(2013).A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(8),5254-5259.
MLA	Zhang, XY,et al."A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.8(2013):5254-5259.