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题名	具有AIE效应的功能化聚酯的合成与表征 王雪
作者	王雪
学位类别	硕士
答辩日期	2015-05
授予单位	中国科学院研究生院
授予地点	中国科学院长春应用化学研究所
导师	崔冬梅
关键词	稀土配合物 丙交酯 碳酸酯 开环聚合 聚集诱导发光
中文摘要	本文合成一类Salan型稀土金属烷基配合物，并以此配合物作为催化剂催化外消旋丙交酯与环碳酸酯类单体顺序开环聚合，构筑精确结构的可生物降解嵌段高分子，并进一步功能化制备具有聚集诱导发光性质的高分子新材料。具体如下： （1）合成含有三键的功能化环碳酸酯单体，并以聚乙二醇作为链转移剂，Salan型稀土金属烷基配合物为催化剂，催化功能化环碳酸酯与外消旋丙交酯次序开环聚合，制备聚乙二醇–聚丙交酯–聚碳酸酯三嵌段双亲共聚物。室温条件下，催化剂表现出优良的催化活性，且合成的聚合物结构可控，分子量分布窄，在生物医用材料有广阔的应用前景。 （2）通过“Click”反应制备具有聚集诱导发光性质的聚乙二醇–聚丙交酯–聚碳酸酯三嵌段双亲共聚物。经荧光仪测试后得到的荧光光谱图中可知，当混合溶剂中水的含量大于80%时样品的荧光强度发生了突然的跃增，并且水含量越高，信号峰越强，证明此类材料具有典型的AIE性质。进一步的，我们探索了其在水中自组装能力，并且制备出尺寸及分布可控的聚合物纳米胶束，其在生物诊断和细胞成像领域有广阔的应用前景
英文摘要	Metal alkyl complexes based on rare earth metal and Salan ligandwere synthesized via alkane elimination reaction. Initiated with the Salan-typed alkyl complex, sequential ring-opening polymerization of rac-lactide and cyclic ester in a living mode has been achieved for constructing biodegradable multiblock polymers. After modified with functional AIE-group, the amphiphilic material with AIE effect have been successfully synthesized and their properties have been extensively investigated. (1) Synthesis of functional cyclic carbonate MPC with pendent-alkyne bond. Through ring-opening polymerization, a PEG–PLA–PMPC triblockpolymer have been obtained, in which polyethylene glycol act as chain transfer agent and Salan-typed rare earth metal alkyl complex play a role of catalyst. The catalyst showed good catalytic activity with living polymerization in mild conditions. Also, the polymer’s structure can be easily controlled, and the polymer’s molecular weight distribution are very narrow. These materials show an excellent potential in the field of medicine and biological applications. (2) The PEG–PLA–PMPC amphiphilicpolymer with aggregation induced luminescence effect have been synthesized through “Click” reaction of AIE unit with polymers. After fluorescence spectrometer measurements, the sample shows a strong fluorescent signal enhancement when the content of water is higher than 80%. More important, with the higher water content, the photoluminescent signal peak are stronger. These results proved that these materials have typical AIE characterizes. At last, The self-assembly properties of these materials in water have been tested. The size and distribution of prepared micelle can be empirically controlled. These results show that the PEG–PLA–PMPC amphiphilicmaterials are very suitable for the application of biological diagnosis and cell imaging.
语种	中文
公开日期	2016-05-03
内容类型	学位论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64464]
专题	长春应用化学研究所_长春应用化学研究所知识产出_学位论文
推荐引用方式 GB/T 7714	王雪. 具有AIE效应的功能化聚酯的合成与表征 王雪[D]. 中国科学院长春应用化学研究所. 中国科学院研究生院. 2015.

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