Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats
	Yin, Nuoya; Yao, Xinglei; Zhou, Qunfang; Faiola, Francesco; Jiang, Guibin
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2015-03-06
卷号	458 期号:2 页码:405-410
关键词	Silver nanoparticles Body weight Neurotoxicity Glial fibrillary acidic protein (GFAP) Vitamin E
英文摘要	Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials; however, it remains unclear whether AgNPs induce neurotoxicity. Here, we investigated the potential neurological effects of AgNPs and the neuroprotective effect of vitamin E (VE). We found that intranasal instillation of AgNPs in neonatal Sprague-Dawley rats caused significant body weight loss. Moreover, histological examinations revealed activation of neuroglial cells with concomitant destruction of the granular layer of the cerebellum. Furthermore, western blot analyses showed an increase in the levels of the glial fibrillary acidic protein (GFAP), a marker of astrocyte activation. These observations suggest that AgNPs have significant neurotoxic effects on the rat cerebellum. Strikingly, oral administration of VE counterbalanced the toxic effects triggered by AgNPs. Taken together, our findings suggest that nasal administration of AgNPs may produce neurotoxicity in rats, and that VE supplementation attenuates these effects. (C) 2015 The Authors. Published by Elsevier Inc.
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000351482200031
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32696]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Yin, Nuoya,Yao, Xinglei,Zhou, Qunfang,et al. Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,458(2):405-410.
APA	Yin, Nuoya,Yao, Xinglei,Zhou, Qunfang,Faiola, Francesco,&Jiang, Guibin.(2015).Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,458(2),405-410.
MLA	Yin, Nuoya,et al."Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458.2(2015):405-410.