High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core

	High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core
	Wang, Long-Hai 1,2; Wu, De-Cheng 3,4; Xu, Hang-Xun 1,2; You, Ye-Zi 1,2
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2016-01-11
卷号	55 期号:2 页码:755-759
关键词	biotechnology DNA-binding affinity gene delivery nanomicelles nanostructures
英文摘要	During the last two decades, cationic polymers have become one of the most promising synthetic vectors for gene transfection. However, the weak interactions formed between DNA and cationic polymers result in low transfection efficacy. Furthermore, the polyplexes formed between cationic polymers and DNA generally exhibit poor stability and toxicity because of the large excess of cationic polymer typically required for complete DNA condensation. Herein, we report the preparation of a novel class of bioreducible cationic nanomicelles by the use of disulfide bonds to connect the cationic shell to the fluorocarbon core. These bioreducible nanomicelles form strong interactions with DNA and completely condense DNA at an N/P ratio of 1. The resulting nanomicelle/DNA polyplexes exhibited high biocompatibility and performed very effectively as a gene-delivery system.
收录类别	SCI
语种	英语
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29758]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Univ Sci & Technol China, Chinese Acad Sci, Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China 3.Chinese Acad Sci, State Key Lab Polymer Phys, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Long-Hai,Wu, De-Cheng,Xu, Hang-Xun,et al. High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(2):755-759.
APA	Wang, Long-Hai,Wu, De-Cheng,Xu, Hang-Xun,&You, Ye-Zi.(2016).High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(2),755-759.
MLA	Wang, Long-Hai,et al."High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.2(2016):755-759.