Online Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry with In situ Mixing

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	Online Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry with In situ Mixing
	Liang, Miao; Shu, Jinian; Zhang, Peng; Li, Yueyan; Sun, Wanqi
刊名	ANALYTICAL LETTERS
	2015-11-02
卷号	48 期号:16 页码:2553-2565
关键词	MALDI Bioaerosol Matrix-assisted laser desorption/ionization Time-of-flight mass spectrometry TOF MS Online analysis
英文摘要	Online matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is reported with in situ matrix/analyte aerosol mixing. The analyte and matrix were dissolved in separate solvents and pneumatically atomized into particles. Continuous flows of analyte particles and matrix droplets in nitrogen were mixed in a tee. The resulting particles were sampled using a nozzle, focused into a beam with an aerodynamic lens system, and vertically deposited continuously on a movable target. The matrix/analyte mixture was desorbed/ionized using a 266 nanometers pulsed laser at an incident angle of 45 degrees. The nascent ions were analyzed using reflectron TOF MS. The performance of online MALDI-TOF MS was evaluated by the analysis of palmityl palmitate with the lithium salt of 2, 4-dihydroxybenzoic acid as the matrix. Strong and stable MALDI signals of palmityl palmitate were obtained. The matrix solvent mixture and the analyte concentration were optimized and the results demonstrate the development of an alternative for online MALDI analysis.
研究领域[WOS]	Chemistry, Analytical
WOS记录号	WOS:000360295100004
公开日期	2016-03-08
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32457]
专题	生态环境研究中心_大气环境科学实验室
推荐引用方式 GB/T 7714	Liang, Miao,Shu, Jinian,Zhang, Peng,et al. Online Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry with In situ Mixing[J]. ANALYTICAL LETTERS,2015,48(16):2553-2565.
APA	Liang, Miao,Shu, Jinian,Zhang, Peng,Li, Yueyan,&Sun, Wanqi.(2015).Online Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry with In situ Mixing.ANALYTICAL LETTERS,48(16),2553-2565.
MLA	Liang, Miao,et al."Online Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry with In situ Mixing".ANALYTICAL LETTERS 48.16(2015):2553-2565.