Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study

	Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study
	Sui, Xiuchao 1,2; Zhu, Maohu 1,2; Cui, Yue1,2 ; Yu, Chunshui 3,4; Sui, Jing1,2,5 ; Zhang, Xinqing 6; Liu, Jieqiong 6; Duan, Yunyun 4; Zhang, Zengqiang 7,8; Wang, Luning 7
刊名	CURRENT ALZHEIMER RESEARCH
	2015
卷号	12 期号:10 页码:974-983
关键词	Alzheimer's disease biomarker classification functional connectivity density mild cognitive impairment resting state functional MRI
英文摘要	Cortical hubs that link functionally specialized neural systems are crucial for cognition. Evidence suggests that the location and organization of hubs are related to Alzheimer's disease (AD). However, two issues remain unclear: (i) where and how hubs change in AD, and (ii) whether hubs could be a potential pre-diagnosis biomarker for mild cognitive impairment (MCI) - a prodromal phase of AD. Accordingly, we examined the functional connectivity density (FCD) in two cohorts of resting-state functional magnetic resonance imaging (fMRI) scans (26 AD, 27 controls; 33 AD, 21 controls) and revealed consistently vulnerable FCD hub regions in AD compared with controls: within the default mode network, short-range FCD decreases in the posterior cingulate cortex and increases in the medial prefrontal cortex; within the frontal lobe, long-range FCD increases in the medial prefrontal cortex, superior frontal gyrus and middle frontal gyrus. Furthermore, FCD correlates with cognitive score and could distinguish MCI from controls with high accuracy (71.08% in dataset 1, 81% in dataset 2). By reflecting a robust and reproducible global shift in brain functions, FCD provides an fMRI biomarker for the underlying mechanism in AD.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Clinical Neurology ; Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; POSITRON-EMISSION-TOMOGRAPHY ; DEFAULT-MODE NETWORK ; RESTING-STATE FMRI ; BRAIN NETWORKS ; ASSOCIATION WORKGROUPS ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE ; CORTICAL NETWORKS ; CEREBRAL-CORTEX
收录类别	SCI
语种	英语
WOS记录号	WOS:000366135300007
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/10528]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China 5.Mind Res Network, Albuquerque, NM 87106 USA 6.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 7.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China 8.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China 9.Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab Neuro Informat, Chengdu 610054, Peoples R China 10.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Sui, Xiuchao,Zhu, Maohu,Cui, Yue,et al. Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study[J]. CURRENT ALZHEIMER RESEARCH,2015,12(10):974-983.
APA	Sui, Xiuchao.,Zhu, Maohu.,Cui, Yue.,Yu, Chunshui.,Sui, Jing.,...&Jiang, Tianzi.(2015).Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study.CURRENT ALZHEIMER RESEARCH,12(10),974-983.
MLA	Sui, Xiuchao,et al."Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study".CURRENT ALZHEIMER RESEARCH 12.10(2015):974-983.