Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations
	Lv,Jun-Jiang; Yu,Shan; Xin,Ying; Cheng,Rong-Rong; Zhu,Hong-Tao; Wang,Dong; Yang,Chong-Ren; Xu,Min; Zhang,Ying-Jun
刊名	PHYTOCHEMISTRY
	2015-09-01
卷号	117 页码:123-134
关键词	Yu Gan Zi Phyllanthus emblica Euphorbiaceae ECD calculation Antiviral Norbisabolane sesquiterpenoid glycosides Phyllaemblicins
英文摘要	In an effort to identify anti-viral and cytotoxic compounds from Phyllanthus spp., 14 highly oxygenated norbisabolane sesquiterpenoids, phyllaemblicins H1-H14, were isolated from the roots of Phyllanthus emblica Linn, along with phyllaemblicins B and C and glochicoccinoside D. Their structures were determined on the basis of detailed spectroscopic analysis and chemical methods. Determination of absolute configurations of these compounds was facilitated by theoretical calculations of electronic circular dichroism (ECD) spectra using time-dependent density functional theory (TDDFT) for the aglycone components, and pre-column derivative/chiral HPLC analysis for the monosaccharides. The known glochicoccinoside D displayed potent activity against influenza A virus strain H3N2 and hand, foot and mouth virus EV71, with IC50 values of 4.5 +/- 0.6 and 2.6 +/- 0.7 mu g/ml, respectively. Phyllaemblicin H1 showed moderate cytotoxicity against human cancer cell lines A-549 and SMMC-7721, with IC50 values of 4.7 +/- 0.7 and 9.9 +/- 1.3 mu M, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
类目[WOS]	Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]	Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]	ROOTS ; NORSESQUITERPENOIDS ; ACIDUS
收录类别	SCI
语种	英语
WOS记录号	WOS:000361253300014
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25140]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Lv,Jun-Jiang,Yu,Shan,Xin,Ying,et al. Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations[J]. PHYTOCHEMISTRY,2015,117:123-134.
APA	Lv,Jun-Jiang.,Yu,Shan.,Xin,Ying.,Cheng,Rong-Rong.,Zhu,Hong-Tao.,...&Zhang,Ying-Jun.(2015).Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations.PHYTOCHEMISTRY,117,123-134.
MLA	Lv,Jun-Jiang,et al."Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations".PHYTOCHEMISTRY 117(2015):123-134.