Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice
	Yang, Li-Ping; Jiang, Fang-Jie; Wu, Gui-Sheng; Deng, Ke; Wen, Meng; Zhou, Xiaoju; Hong, Xuechuan; Zhu, Michael X.; Luo, Huai-Rong
刊名	PLOS ONE
	2015-08-28
卷号	10 期号:8
英文摘要	Transient receptor potential canonical (TRPC) channels are widely expressed in brain and involved in various aspects of brain function. Both TRPC4 and TRPC5 have been implicated in innate fear function, which represents a key response to environmental stress. However, to what extent the TRPC4/C5 channels are involved in psychiatric disorders remains unexplored. Here, we tested the antidepressant and anxiolytic-like effects of a newly identified TRPC4/C5 inhibitor, M084. We show that a single intraperitoneal administration of M084 at 10 mg/kg body weight to C57BL/6 male mice significantly shortened the immobility time in forced swim test and tail suspension test within as short as 2 hours. The M084-treated mice spent more time exploring in illuminated and open areas in light/dark transition test and elevated plus maze test. In mice subjected to chronic unpredictable stress, M084 treatment reversed the enhanced immobility time in forced swim test and decreased the latency to feed in novelty suppressed feeding test. The treatment of M084 increased BDNF expression in both mRNA and protein levels, as well as phosphorylation levels of AKT and ERK, in prefrontal cortex. Our results indicate that M084 exerts rapid antidepressant and anxiolytic-like effects at least in part by acting on BDNF and its downstream signaling. We propose M084 as a lead compound for further druggability research.
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	MAJOR DEPRESSIVE DISORDER ; PREFRONTAL CORTEX ; ANXIETY DISORDERS ; ANIMAL-MODELS ; C-FOS ; TRPC5 ; BEHAVIOR ; MECHANISMS ; AMYGDALA ; PATHOPHYSIOLOGY
收录类别	SCI
语种	英语
WOS记录号	WOS:000360299100067
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25120]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Yang, Li-Ping,Jiang, Fang-Jie,Wu, Gui-Sheng,et al. Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice[J]. PLOS ONE,2015,10(8).
APA	Yang, Li-Ping.,Jiang, Fang-Jie.,Wu, Gui-Sheng.,Deng, Ke.,Wen, Meng.,...&Luo, Huai-Rong.(2015).Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.PLOS ONE,10(8).
MLA	Yang, Li-Ping,et al."Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice".PLOS ONE 10.8(2015).