Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng
	Gu, Cheng-Zhen; Lv, Jun-Jiang; Zhang, Xiao-Xia; Qiao, Yi-Jun; Yan, Hui; Li, Yan; Wang, Dong; Zh, Hong-Tao; Luo, Huai-Rong; Yang, Chong-Ren
刊名	JOURNAL OF NATURAL PRODUCTS
	2015-08-01
卷号	78 期号:8 页码:1829-1840
英文摘要	The roots of Panax notoginseng, an important Chinese medicinal plant, have been used traditionally in both the raw and processed forms, due to the different chemical constituents and bioactivities found. Thirty-eight dammarane-type triterpenoid saponins were isolated from the steam-processed roots of P. notoginseng, including 18 new substances, namely, notoginsenosides SP1-SP18 (1-18). The structures of 1-18 were determined on the basis of spectroscopic analysis and acidic hydrolysis. The absolute configuration of the hydroxy group at C-24 in 1-4, 19, and 20 was determined in each case by Mo-2(AcO)(4)-induced circular dichroism. The new compounds were found to feature a diversity of highly oxygenated side chains, formed by hydrolysis of the C-20 sugar moiety followed by dehydration, dehydrogenation, epoxidation, hydroxylation, or methoxylation of the main saponins in the raw roots. The new saponins 1, 2, 6-8, 14, and 17 and the known compounds 20-27 showed promoting effects on the differentiation of PC12 cells, at a concentration of 10 mu M.
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	PERFORMANCE LIQUID-CHROMATOGRAPHY ; GENERATE MOLECULAR DIVERSITY ; ABSOLUTE-CONFIGURATION ; DAMMARANE GLYCOSIDES ; MASS-SPECTROMETRY ; TOTAL SAPONINS ; IN-VITRO ; GINSENG ; RAW ; CONSTITUENTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000360773700005
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25118]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Gu, Cheng-Zhen,Lv, Jun-Jiang,Zhang, Xiao-Xia,et al. Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(8):1829-1840.
APA	Gu, Cheng-Zhen.,Lv, Jun-Jiang.,Zhang, Xiao-Xia.,Qiao, Yi-Jun.,Yan, Hui.,...&Zhang, Ying-Jun.(2015).Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng.JOURNAL OF NATURAL PRODUCTS,78(8),1829-1840.
MLA	Gu, Cheng-Zhen,et al."Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng".JOURNAL OF NATURAL PRODUCTS 78.8(2015):1829-1840.