Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives
	Liu, Lan-Xiang; Wang, Xue-Quan; Zhou, Bei; Yang, Li-Juan; Li, Yan; Zhang, Hong-Bin; Yang, Xiao-Dong
刊名	SCIENTIFIC REPORTS
	2015-08-19
卷号	5
英文摘要	A series of novel N-substituted carbazole imidazolium salt derivatives has been prepared and investigated for their cytotoxic activity against five human tumor cell lines by MTS assay. The results indicated that the existence of 5,6-dimethyl-benzimidazole ring, substitution of the imidazolyl-3-position with a 2-bromobenzyl or naphthylacyl group, as well as alkyl chain length between carbazole and imidazole ring were important for the antitumor activity. Compound 61, bearing a 2-bromobenzyl substituent at position-3 of the 5,6-dimethyl-benzimidazole, showed powerful inhibitory activities and was more selective to HL-60, SMMC-7721, MCF-7 and SW480 cell lines with IC50 values 0.51-2.48 mu M. Mechanism of action studies revealed that this new compound could remarkably induce cell cycle arrest and apoptosis in SMMC-7721 cells. This work provides alternative novel way for future drug development based on carbazole and imidazolium salt scaffolds.
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	ORGANIC-SYNTHESIS ; HYBRID COMPOUNDS ; DESIGN ; ALKALOIDS ; INDUCTION
收录类别	SCI
语种	英语
WOS记录号	WOS:000359692000001
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25098]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Liu, Lan-Xiang,Wang, Xue-Quan,Zhou, Bei,et al. Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives[J]. SCIENTIFIC REPORTS,2015,5.
APA	Liu, Lan-Xiang.,Wang, Xue-Quan.,Zhou, Bei.,Yang, Li-Juan.,Li, Yan.,...&Yang, Xiao-Dong.(2015).Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives.SCIENTIFIC REPORTS,5.
MLA	Liu, Lan-Xiang,et al."Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives".SCIENTIFIC REPORTS 5(2015).