Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis

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	Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis
	Hao, Lian-xu1,2,3 ; Li, Mo-fei1,2,3
刊名	FISH & SHELLFISH IMMUNOLOGY
	2015-12-01
卷号	47 期号:2 页码:717-724
关键词	CC chemokine Cynoglossus semilaevis Antiviral Antibacterial Immune defense
英文摘要	Chemokines are a large, diverse group of small cytokines that can be classified into several families, including the CC chemokine family, which plays a pivotal role in host defense by inducing leukocyte chemotaxis under physiological and inflammatory conditions. Here we studied 9 CC chemokines from half-smooth tongue sole (Cynoglossus semilaevis). Phylogenetic analysis divided these chemokines into four groups. The tissue specific expression patterns of the 9 chemokines under normal physiological conditions varied much, with most chemokines highly expressed in immune organs, while some other chemokines showing high expression levels in non-immune organs. In addition, the 9 chemokines exhibited similar or distinctly different expression profiles in response to the challenge of virus and intracellular and extracellular bacterial pathogens. These results indicate that in tongue sole, CC chemokines may be involved in different immune responses as homeostatic or inflammatory chemokines. (C) 2015 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000366874500011
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/86637]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Hao, Lian-xu,Li, Mo-fei. Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis[J]. FISH & SHELLFISH IMMUNOLOGY,2015,47(2):717-724.
APA	Hao, Lian-xu,&Li, Mo-fei.(2015).Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis.FISH & SHELLFISH IMMUNOLOGY,47(2),717-724.
MLA	Hao, Lian-xu,et al."Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis".FISH & SHELLFISH IMMUNOLOGY 47.2(2015):717-724.